eMedicine World Medical Library

Asthma and Sinusitis

Last Updated: June 8, 2004
Synonyms and related keywords: respiratory distress, bronchitis, allergic bronchitis, sinus problems, sinus infection, postnasal drip, rhinitis, allergic rhinitis, mucociliary clearance, asthmatic, reactive airway disease, wheeze, bronchiolitis, bronchial asthma, acute asthma, allergies, bronchial airways, bronchial airway narrowing, inflammation of the bronchi, bronchial smooth muscle contraction, wheezing, dyspnea, airway narrowing, noisy breathing, difficult breathing, difficulty breathing, respiratory disease

 

  AUTHOR INFORMATION  

Author: Murray Grossan, MD, Consulting Staff, Department of Otolaryngology, Cedars Sinai Hospital of Los Angeles

 

Murray Grossan, MD, is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery

 

Editor(s): Lanny Garth Close, MD, Chair, Professor, Department of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, Pharmacy, eMedicine; Stephen G Batuello, MD, Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, The Medical Center of Aurora; Christopher L Slack, MD, Consulting Staff, Otolaryngology-Facial Plastic Surgery, Lawnwood Regional Medical Center; and Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
  INTRODUCTION  

Background: In the United States, 35 million persons have sinus problems and 15 million persons have asthma. Clinically, physicians know that a sinus infection can contribute significantly to the frequency and severity of asthma attacks. The purpose of this article is to outline the factors common to both conditions and to note how best to improve these conditions.

Asthma and sinusitis both have been recognized in ancient literature. In the 1940s and 1950s, considerable sinus surgery was performed to help people with asthma. Purulent diseased tissue was removed, the nasal airway was opened, and excellent results were achieved for some of these patients. Then, in the 1960s, the improvements following sinus surgery were thought to be related more to the stress reaction than to the surgical technique; therefore, sinus surgery became less popular as a principle of asthma management.

With the introduction of the CT scanning technique in the 1970s, accurately pinpointing the location and extent of the sinus pathology became possible. A return to corrective surgery for individuals with sinusitis and individuals with asthma has occurred, thanks to the studies of Rachelevsky, Spector, and many others showing the benefits of clearing sinus pathology. Then, in the 1980s, functional endoscopic sinus surgery (FESS) and the ability to physiologically improve sinus function became available.

In the 1990s, as CT scanning has enhanced the view of the sinus and as endoscopic surgery, especially with the computer-assisted techniques, has improved the ability to improve sinus function, physicians are returning to sinus treatment as an aid to asthma management. Further aids to treatment have included newer antibiotics and emphasis on cilia function. Newer medications, such as the corticosteroids sprays, have given new directions for treatment. Indeed, many allergists now emphasize their role in treating sinusitis.

 

Pathophysiology: The physiology of mucus in individuals with asthma is similar to that of nasal mucus. Mucociliary clearance (MCC) involves cilia and the layers of mucus on the ciliated epithelium and refers to the movement of particles along a desired path for maximum health. In the upper respiratory tract, cilia propel the mucus and its trapped bacteria and particles to the nasopharynx, where it drops to the hypopharynx and is swallowed. The stomach acid then disposes of the unwanted invaders.

In the lower respiratory tract, the cilia that line the trachea and bronchial tree similarly move the mucus blanket up the trachea and into the hypopharynx for swallowing.

The science of rheology investigates the makeup of this liquid and studies its viscosity and elasticity. Two layers of mucus are present over the ciliated cell; an outer thick, viscoelastic, semisolid mucus layer, which the cilia do not strike directly, is found over a layer of watery serous fluid. Because of the lowered viscosity of the layer of watery serous fluid, the cilia are able to beat normally and to move the watery lower layer, thereby affecting movement of the upper thick layer. Changes of these properties affect movement of the mucus blanket and play a major role in pulmonary and sinus disease. If the movement of the blanket is slowed, bacteria are able to multiply as the mucus thickens and stagnates.

Nasal mucus is a secretory substance produced by 100,000 small seromucous glands in nasal mucosa. Nasal mucus has a lower viscosity than sputum and contains sulfate, sugars, proteins (including albumin), and protective enzymes and phagocytes.

MCC refers to the function of moving bacteria, contaminants, and carcinogens away. Ciliary beat frequency refers to the number of full whiplike movements of the cilia per second (normally 16) and involves the coordination of these movements.

Remarkably, the ciliary movement is coordinated so that an effective wave propels the mucus in a specific direction. Sinus cilia beat toward the natural sinus opening in the middle meatus, even after an antrostomy or artificial opening is created in the inferior meatus. Nasal cilia beat backward towards the nasopharynx. Thus, nasal mucus is propelled into the nasopharynx and is swallowed for disposal into the stomach. In the child, this course directs the mucus with its bacteria, debris, and foreign matter over the adenoids where lymphocytic defenses can act. The deep crypts and rugae of the adenoids create a larger surface area for greater effect.

Protection from infection is achieved by the presence of lysozymes, immunoglobulins, and phagocytes in the mucus solution. Movement of the bacteria by mucus flow reduces opportunity for penetration of the cell. Dilution of bacterial products makes them less toxic. Anything that thins the nasal mucus or stimulates it (eg, proteolytic enzymes, mucolytics) helps the asthmatic chest mucus. Measuring cilia in the chest is quite difficult; measurement requires biopsy or special radioactive gasses. Measuring the nasal cilia, as by a saccharin test, is easy and is a useful reflection of the chest cilia.

 

Frequency:
 

  • In the US: Asthma and sinusitis are both increasing in frequency. Fifteen million individuals with asthma and 35 million persons with sinusitis live in the United States. No doubt, overlapping of the conditions occurs.
  • Internationally: An increased incidence is reported in all countries. The incidence of sinusitis is higher in Japan, Indonesia, and Europe than in the United States. An increasing incidence of both sinusitis and asthma occurring together is reported internationally as well as in the United States. Certain areas have special conditions causing an increased sinusitis incidence (eg, the fires of Kuwait and Indonesia, the chromium content of the sands of Saudi Arabia). Asthma-free areas have been noted in certain sub-Saharan areas where hookworm is endemic. The parasite system (eg, eosinophiles) is fully engaged.

Mortality/Morbidity: Despite the availability of effective antiasthmatic drugs, asthma is responsible for more than 100 million days of restricted activity and 470,000 hospitalizations annually. The most common disease of early childhood, asthma exacts a particularly high toll among persons who are economically disadvantaged.

  • In poverty situations, the incidence of asthma and allergy is higher. This increased incidence is partially based on poor environmental control. Cockroaches and dust are known to be causes of asthma. In situations of poverty, pets are often prevalent in close quarters, and air filtering and dust proofing often are not performed. Asthma is a disease that requires maximum cooperation of the family. Often, the parents must oversee a complicated regimen of inhalers, pills, and breathing exercises; this type of supervision and assistance may not be available in poverty situations. Poor medical service also is a major factor contributing to the high rate of poorly controlled asthma and sinusitis in these patients. Often, the only primary and follow-up care for this population of patients is in the busy emergency department.
  • Sinusitis, fortunately, has a low death rate. Death can occur in young children when the condition is unrecognized. In infants, the maxillary sinuses are well developed but are often unrecognized as a source of possible lethal infection. In adults, fatalities occur primarily as a result of complications of sinus infection to the brain, meninges, and the cavernous sinus.
  • Problems with sinusitis and rhinitis can make up 50% of office visits and are involved in a large percentage of medical costs.

Sex: Incidence of sinusitis appears to be equal between the sexes.

Age: Asthma and sinusitis can occur in very young children. Sinusitis in very young children is not appreciated because the presence of the maxillary and ethmoid sinuses is not always recognized. Once children start nursery school, the incidence of sinus and chest infections increases dramatically.

  CLINICAL  

History: Individuals with asthma often have a childhood history of allergy. Patients present with wheezing and coughing, and they report sleepless nights. These patients benefit from the use of an inhaler. Associated with these symptoms are symptoms of frequent sinus infections, heavy pus, or thick mucus drainage into the chest. Whenever individuals with asthma get a sinus infection, the asthma worsens. When accompanied by a sinus infection, the asthma does not clear with simple treatment. When the nose obstructs, these individuals breathe with the mouth open, which precipitates an asthma attack. Patients with asthma have a dry mouth all the time and are bothered by thick nasal phlegm dripping into the throat. The thick phlegm causes these patients to cough and try to clear the throat constantly. With a sinus infection, a much longer time period is required to clear the asthma. Obtain history regarding frequency of bouts of nasal obstruction, purulent discharge, localized sinus pain, drainage, and fever.

  • Determine the frequency of symptoms.
    • History of frequent bouts of sinusitis is evidenced.
    • Every year, 4-5 episodes of sinusitis occur and last about 4 weeks each.
    • Often, the episodes do not clear until antibiotics are administered.
  • A history of nonchronic sinusitis is as follows:
    • A history of 4 bouts of sinusitis over the past 6 months, each of which required antibiotics and did clear, is more suggestive of a single infection hanging on.
    • When the antibiotic is stopped, the infection, still present, gradually returns.
    • In this case, irrigation is needed as well as possible local treatment or a longer course of antibiotic.
  • Family history includes the following:
    • Obtaining family history is very important in cases of asthma and allergies.

       

    • For sinusitis, a higher incidence generally does not follow a family history of sinusitis.
  • The following 2 factors cause a very high incidence of sinusitis in patients with AIDS:
    • Lowered immune systems allow bacterial growth.
    • A thickened mucus exudate becomes stagnant and allows for bacterial growth.
  • The failure of the normal mucociliary flow system accounts for an extremely high incidence of sinus disease in patients with cystic fibrosis.

Physical: In susceptible individuals, this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread, but variable, airflow obstruction that is often reversible either spontaneously or with treatment. The inflammation also causes an associated increase in the existing bronchial hyperresponsiveness to a variety of stimuli.

  • Determine whether sinus infection precedes or follows asthma attack.
  • Determine the frequency of sinusitis and results of antibiotic therapy.
  • Examine the eyes, ears, nose, throat, and larynx. Look for lymphoid hyperplasia and/or hypertrophic turbinates. Determine if they are inflammatory or allergic in appearance.
  • Determine if the septum is obstructive. On laryngoscopy, look for signs of irritation of the posterior larynx indicating gastroesophageal reflux disease (GERD).
  • Look for history of eustachian tube dysfunction.
  • Look for signs of adenoid hypertrophy or mass.
  • Hypertrophic posterior turbinates may best be observed via nasopharyngeal mirror examination.
  • In cases of unilateral purulent drainage from a child, especially look for a foreign body.
  • Perform nasal endoscopy to reveal patent or closed sinus ostia (see Image 1).
  • Visualize the maxillary, frontal, and sphenoid ostia.
  • Physical findings of asthma include the following:
    • Individuals with asthma wheeze and have impaired breathing.
    • The chest is sometimes retracted or sunken, indicating inhalation difficulty. (Barrel chest indicates emphysema.)
    • Nostrils flare.
    • Throat is often dry.
  • Physical findings of sinusitis include the following:
    • Patient breathes through the mouth and shows purulent drainage.
    • Patient may have a mild fever.

    • Local tenderness over the affected sinus is present.
    • With nasal speculum, a purulent drainage is usually observed from the middle meatus.
    • Transillumination shows decreased light passage on the affected side.

    • Purulent material may be observed in the pharynx and/or the nasopharynx.

Causes: Asthma and sinusitis are increasing in frequency and morbidity, despite the advances made in understanding and treating these conditions. The following theories suggest what is causing these increases:

  • Overuse of antibiotics
    • A current theory suggests that with overuse of antibiotics, the normal disease reaction is replaced by a hypersensitivity reaction.
    • This theory notes a high incidence of disease in families with upper incomes; these individuals have full access to medical care, cleanliness, and dust proofing.
    • The body's immune system is designed to fight parasites and infections, and if the antibiotic is administered at the first sign of illness, perhaps the normal immunity does not develop and alternate systems are produced (eg, asthma, poor resistance to infection).
  • Genetics
    • When compared to sinusitis, asthma has more of a genetic etiology.
    • Incidence of asthma increases when both parents have asthma.
    • More individuals with asthma are having children.
  • Environmental factors: These factors are becoming increasingly more important and include the following:
    • The major environmental irritant, other than specific occupational substances, is tobacco smoke.
    • Current theory attributes the increase of sinusitis and asthma to air pollution. When the air is polluted with smog, diesel, gasoline, and other noxious products, the sun's heat and rays may combine them into dozens of products whose long-term effects are unknown at this time.
    • Additionally, smog, diesel fumes, and sulfur dioxide all combine to interfere with good cilia function. Hypersensitivity reactions seem to occur when the individual has an overwhelming exposure and does not recover ciliary function. Unfortunately, new solvents are marketed daily and the effect on cilia function is not provided by the manufacturers. Even more unfortunate is the fact that despite the 50 million dollars spent by the Federal Drug Administration (FDA) on clinical evaluations, no drugs are evaluated as to their effect on mucociliary clearance.
    • Known industrial toxins include chlorine, sulfur dioxide, cupric compounds, and chromium dusts.
    • Fires are a known factor. When countrywide fires occur, such as in Kuwait or Indonesia, the incidence of sinusitis and asthma increases. Oil fires in Kuwait released polymelia aromatic hydrocarbons, nickel, and vanadium into the atmosphere. This contamination resulted in upper and lower respiratory infections. Similar problems have occurred with Indonesia forest fires and excess smog experienced in London. Some of the respiratory problems might be prevented by simple irrigation with Locke-Ringer–type solutions.
    • Other environmental problems to be considered include pet allergens, house dust mite allergen, cockroach allergen (most significant in patients who live in the inner city), indoor fungi and molds, and outdoor allergens (eg, trees, grass, weed pollens, seasonal mold spores).
  • Impaired mucociliary clearance: Sinusitis and asthma are inflammatory diseases and, as such, are caused or aggravated when mucociliary clearance is impaired. Factors that slow cilia include the following:
    • Cocaine

    • Antihistamines

    • Dehydration

    • Inhalation of air or steam hotter than 40 degrees Celsius

    • Heavy load of iced drinks

    • Chilling drafts

    • Sulfur dioxide, ozone, smog

    • Inhalation of chromium dusts

    • Cupric (copper) compounds

    • Nickel dusts
    • Chimney dusts

    • Formaldehyde

    • Late stages of allergy

    • Nasal polyps

    • Skydrol (a solvent used in airplane maintenance)

    • Infections with Pseudomonas species, Haemophilus influenzae, and many viral pathogens

    • Hyperbaric oxygen

    • Reduction of airway diameter

    • AIDS
  • GERD: In addition to the above factors, recognition of GERD as an irritant that brings on asthmatic symptoms, as well as throat and laryngeal symptoms, is increasing. When the larynx is visualized with mirror or endoscope, the arytenoids are inflamed, especially posteriorly. Standard GERD measures may be beneficial.
  • Bacteria: Dye or tracers placed in the sinus appear 16 hours later in the lower trachea. Thus, little question exists that bacteria from the sinuses find their way to the lower respiratory system. Bacteria then act as an inflammatory agent.
  DIFFERENTIALS  

Foreign Bodies of the Airway
 


Other Problems to be Considered:

Differential diagnosis of asthma includes the following:

Chronic obstructive pulmonary disease (chronic bronchitis or emphysema)
Congestive heart failure
Cough secondary to drugs (eg, angiotensin-converting enzyme inhibitors)
Laryngeal dysfunction (eg, ventricular dysphonia)
Mechanical obstruction of the airways (eg, tumors, anatomic changes)
Retrosternal thyroid
Pulmonary embolism
Pulmonary infiltration with eosinophilia
Bronchostenosis
Enlarged lymph nodes
Foreign body in trachea or bronchus
Laryngeal webs
Laryngotracheomalacia (primarily in infants)
Tracheal stenosis in infants
Tumor
Vascular rings
Vocal cord dysfunction
Bronchopulmonary dysplasia
Cystic fibrosis
Heart disease
Obliterative bronchiolitis
Viral bronchiolitis
Aspiration from swallowing mechanism dysfunction
GERD
Recurrent cough not due to asthma
Environmental irritants

Differential diagnosis of sinusitis includes the following:

Cervical or temporal mandibular joint (TMJ) referred pain
Allergic rhinitis
Nasal polyps
Foreign body (common in children; characterized by unilateral purulent odorous drainage)
Acute common cold
Deviated nasal septum
Rhinitis medicamentosum


 
  WORKUP  

Lab Studies:
 

  • Culture purulent discharge.
    • Unfortunately, culture taken directly from the nose may not yield correct information. Most healthy persons harbor potentially harmful bacteria.
    • The best culture is taken directly from the sinus cavity by insertion of a sterile needle and aspiration into a sterile container.
    • Sensitivity studies are usually needed and are of value when the specimen has been taken by puncture aspiration.
    • In individuals who are diabetic and/or immunocompromised, the culture program includes culture for fungus.
    • If the patient has had many antibiotics and has chronic sinusitis, a fungus growth may show up on fungus culture. However, this may not be the cause of the sinusitis.
    • Generally, bacterial exudates are in the nasal chambers. Cultures show H influenzae, Neisseria catarrhalis, and Haemophilus pneumoniae. Cultures may also show streptococci infections
  • White blood cell count and differential count is as follows:
    • As in any infection, WBC differential count helps differentiate between viral and bacterial infection.
    • Test for infectious mononucleosis when adenopathy and tonsillitis accompany the sinus infection.
  • In cases of chronic sinusitis, some authors test the skin for fungus and then desensitize it for strong positive reactors.
  • Biopsy of the nasal membrane may be used to obtain tissue to be measured for cilia activity. This is often a research procedure.
  • The saccharine test of nasomucociliary flow is indicated if a history of toxic exposure exists or if cystic fibrosis is suggested. This test can be used to gauge the degree of reduced cilia activity.
    • In most cases of chronic sinusitis, the saccharin test of mucociliary flow shows impaired cilia action. This usually reflects the cilia of the chest.
    • Place a particle of saccharin one-fourth inch behind the anterior edge of the turbinate. Instruct the patient to sit quietly to not sniff or sneeze. Ask the patient to swallow every 30 seconds and report when the sweet saccharin is tasted. The patient's report measures the speed of the nasal cilia as they propel the particle to the nasopharynx. The following measures are related to cilia activity:

       

      • In acute allergy, the saccharin is tasted in 5 minutes or less.

      • With normal nasal conditions, the saccharin is tasted in 5-8 minutes.

      • With infection and late stage allergy, the saccharin is tasted in 9-19 minutes.

      • With atrophic rhinitis and chronic sinusitis, the saccharin is tasted in 20-29 minutes.

      • After exposure to chlorine gas or other toxins, saccharin is tasted in more than 30 minutes. These patients do not recover their cilia function with treatment.

Imaging Studies:
 

  • Radiography of the sinuses is quite helpful and generally includes Waters, lateral, and Caldwell views.
    • To perform the Waters view, place the patient's chin on the radiograph plate and the nose 1-1.5 cm above the plate. This positioning provides the best view of the maxillary sinus with the petrous ridge being below the inferior portion of the maxillary sinus.
    • The lateral view ideally shows the frontal and sphenoidal sinuses as well as the ethmoid sinuses in lateral projection. However, these views have been replaced with CT scan views that often provide exquisite detail of the sinus anatomy.
    • The Caldwell view, in which the nose and forehead are on the radiograph plate, is designed to visualize the frontal and ethmoidal sinuses.
  • CT scanning involves the following:
    • CT scanning has replaced regular radiography as the preferred imaging test to look at the sinuses.
    • In most communities, the radiologist obtains a limited CT scan for about the price of a regular sinus radiograph.
    • In cases of sinusitis, localizing the condition by means of CT scanning and correcting anatomic factors is important.
    • The limited CT scan shows the maxillary ostia. Look for pathology of the nasoantral opening of the maxillary sinus. If this opening is compromised, then referral to the otolaryngologist is indicated.
    • With a CT scan, the bony anatomy, including the important structures of the maxillary frontal and sphenoid ostia, is detailed. The cribriform plate, whose anatomic position is a critical factor in any surgery, is visualized. The surgeon looks for depression at this area and dehiscence.
    • In chronic sinusitis, a CT scan of the sinuses is often needed to pinpoint foci of infection and patency of ostia.
    • Primarily look for conditions that may impair drainage, especially from the maxillary ostia. These conditions may be nasal polyps, thickened mucosa, enlarged turbinates, concha bullosa, or even a deviated septum (see Image 2). The diseased sinuses can be clearly identified. If the ostia are patent, the patient should respond to systemic management. If the sinus openings are fully closed, then systemic therapy may be insufficient, and surgical correction may be required.
  • MRI involves the following:
    • MRI of the sinuses produces excessive false-positive results because the MRI is too sensitive. Commonly, patients who have had an MRI for unrelated causes are referred to the ear, nose, and throat (ENT) office with a diagnosis of sinusitis from the MRI results but with a negative history of purulent drainage, nasal congestion, or fever. This is because any liquid can show up as disease on an MRI. If the patient is reported as having sinusitis based on the MRI only, this finding can be ignored.
    • MRI is of use in diagnosing fungal infection. Usually a sinus filled with fungus has a characteristic appearance.

Other Tests:
 

  • Allergy tests may be indicated and can be performed in the office by intradermal testing, ie, prick testing or radioallergosorbent assay test (RAST). RAST and other laboratory tests are performed from blood removed from the patient. Results are usually accurate, and a treatment serum can be made based on these results. Persons can have anaphylactic reactions to these tests, and the means of treatment must be immediately available.
  • Food allergies are difficult to test for. A careful history provides the best identification of a food allergy. Once the food is identified, adding the food to the test to induce a reaction is best in order to prove the allergy. Then, prescribe an allergy-free diet with avoidance of test-identified foods.
  • Lyme disease, HIV, infectious mononucleosis, leukemia, and other diseases can all mimic sinus and chest conditions and must be assayed for difficult cases.
  • Cystic fibrosis must be considered in the patient with recurrent sinus and chest infection. The sweat test indicates this diagnosis, as does the saccharin test of cilia function.
  • Pulmonary function studies indicate respiratory function.
  • Daily expiratory flow measurements are necessary in asthma.
    • Take the time to be assured that the patient/parents fully understand how these measurements are performed and how to perform the important daily log-keeping of the maximum expiratory flow rate. Demand that the patient bring the meter to the office from time to time to check on technique.
    • The more expensive flow-rate meter is not necessarily the best model; however, some doctors are recommending the new computerized models that store rate values and are not dependent on the patient's record-keeping skills.

Procedures:
 

  • Laryngoscopy: Look for signs of irritation of the posterior larynx indicating GERD.
  • Nasopharyngeal mirror examination: Hypertrophic posterior turbinates may be observed. In cases of unilateral purulent drainage in a child, especially look for a foreign body.
  • Nasal endoscopy: Patent or closed sinus ostia may be revealed. The maxillary, frontal, and sphenoid ostia are visualized. Purulent discharge is noted (see Image 3).
Histologic Findings: Biopsy may show absence of cilia or squamous changes of nasal cilia. The best diagnosis of cilia dysfunction is obtained when the biopsy tissue is placed into solution and the cilia frequency is measured by strobe or similar means. The strobe frequency is adjusted to match the cilia frequency.

 

  TREATMENT  

Medical Care: Whether sinusitis and asthma are caused by inflammation or allergies has been questioned. Today, sinusitis and asthma are attributed to inflammatory effect. An excellent example of this is the existence of nasal polyps. With administration of corticosteroids (both oral and topical), polyps may not shrink; however, if an antibiotic is added at the same time as the corticosteroids, clearing of the polyps from the nasal cavity with clearing of the blockage occurs in more than 90% of the author's patients. Patients prefer this form of treatment to surgery.

Treatment consists of using measures to increase mucociliary clearance. To help cilia movement in the chest and nose, a deep-throated "oooooommmmm" vibration is useful to help break up thick mucus. Patients should drink enough fluids (eg, hot tea, hot chicken soup) to lighten the urine. Bacterial load should also be reduced. This may be achieved by terbutaline, inhaled corticosteroids, various enzymes (eg, Bromelin or Papain taken buccally), pseudoephedrine, breathing and coughing exercises, flutter inhalation device, iodides, guaifenesin, irrigation, Locke-Ringer moisturizer spray, and exercise.

Many cases of sinusitis do not respond to treatment because (1) the wrong antibiotic is prescribed; (2) duration of the antibiotic is too short (treatment may require 6 wk); (3) drainage, rest, and anti-inflammatories are not combined with treatment; (4) fungus is present; and (5) the mucociliary system fails. If infection does not clear in 6 weeks, referral to ENT is recommended.

Because bacteria and thick phlegm play a significant role, the physician can reduce the asthmatic symptoms from sinusitis by suctioning or irrigating in the office if pus is present in the nose or sinuses. One technique is to use a vasoconstrictor in the nose, wait 2 minutes, and then irrigate with a modified Locke-Ringer solution or sodium chloride solution with pulsatile nasal/sinus irrigator, such as the Hydro Pulse. Not only is a considerable amount of surface and sinus pus removed, but also the pulsatile action at 20 pulses per second stimulates the cilia of the nose and sinuses to restore normal cilia action (see Image 4). This same procedure can be used daily at home for chronic sinusitis in adults and children aged 5 years and older (Rachelevsky, 1989).

Pulsatile irrigation may also be beneficial to the patient with allergies during the pollen season. Daily irrigation reduces the pollen load in the nose and the immunoglobulin E (IgE) levels in the nose and in the circulation (Subiza, 1999).

If asthma and sinusitis are considered as being inflammatory diseases, treatment is clearly similar for both in regards to specific infection, inflammation, drainage, attention to thinning mucus, and restoring cilia and comfort to the patient.

  • Antibiotics

     

    • Most common organisms are Streptococcus pneumoniae, H influenzae, and Moraxella catarrhalis. Increasingly resistant strains of bacteria are developing. Standard treatment for acute sinusitis must include antibiotics for H influenzae and S pneumoniae. Treatment is usually one of the following:

       

      • Amoxicillin 500 mg 3 times a day

      • Trimethoprim-sulfamethoxazole (Septra DS) twice daily

      • Cefuroxime (Ceftin) 250 mg twice daily

      • Cefaclor (Ceclor) 500 mg 3 times a day

    • Other medications include the following:

       

      • Trimethoprim-sulfamethoxazole double strength (Bactrim DS) twice daily

      • Cefixime (Suprax) 400 mg once daily

      • Loracarbef 400 mg twice daily

      • Augmentin 400 mg 3 times a day

      • Clarithromycin (Biaxin) 500 mg 2 times a day

      • Azithromycin (Z-Pak) 250-mg tablets, 2 the first day followed by 1 every day for 4 more days

      • Erythromycin adult dose for chronic sinusitis

    • For chronic sinusitis, usual pathogens, anaerobes, and Staphylococcus aureus are involved. Start amoxicillin 500 mg 3 times a day, amoxicillin with clavulanate (Augmentin) 500 mg 3 times a day, or clindamycin (Cleocin) 150-300 mg every 6 hours. With all antibiotics, patients should take a full glass of water before and after each dose. Antibiotic sensitivities change almost daily and from region to region. Physicians must receive and use the drug resistance/sensitivity data available from hospitals.

    • For treatment of Pseudomonas infections, use piperacillin, ticarcillin, and carbenicillin, depending on the secondary organisms.
  • Anti-inflammatory agents: Sinus pain is present when membranes are inflamed or swollen. Anti-inflammatory agents (eg, Naproxen) are useful.

  • Steroids: One of the major advances in sinus and asthma treatment has been in the use of steroids. These are anti-inflammatory and serve well to reduce these factors.

     

    • Oral steroids: Prednisone is useful for allergic rhino sinusitis and may be administered as prednisone 5 mg number 21. It is prescribed in diminishing doses, as follows: 6 tablets the first day, 5 tablets the next day, and so on to 1 tablet the sixth day. These should all be taken at one time and not spaced out. Medrol Dosepak is used similarly. Systemic corticosteroids include Decadron for quick action and Celestone for delayed action. These are excellent for anti-inflammatory purposes.

    • Steroid sprays: These are very common today. Commonly used are beclomethasone dipropionate (Beconase AQ), triamcinolone acetonide (Nasacort AQ), and fluticasone propionate (Flonase). Budesonide (Rhinocort Aqua) has the advantage of being without benzalkonium. Compared with the oral antihistamines, the sprays have the advantage of effectiveness and few adverse effects. Adverse effects of steroid sprays include atrophic changes and epistaxis. After 3 months of daily use, check to see if thinning of the membranes, crusting, or bleeding is present. If these are present, stop the steroid spray use. A course of saline spray without benzalkonium, a moisturizer ointment can reverse this adverse effect. Rhinocort Aqua does not contain benzalkonium and may have fewer adverse effects.

  • Mucolytic medications: Whenever stasis occurs, mucus thickens and bacteria multiply. Thinning the mucus is important in order to restore mucociliary clearance. Drinking hot tea with lemon and honey is one of the best treatments, as is ingesting chicken soup. Most cold drinks slow cilia.

     

    • Guaifenesin: This is a common mucolytic present in Robitussin and other cough preparations. Some authors dispute its value. The dose needed is 1200 mg twice daily. Preparations combined with decongestants (eg, Entex LA, Zephrex LA, Aqua Tabs) are popular and clinically appear to be beneficial.

    • Proteolytic enzymes: These enzymes (eg, papain, bromelain) reduce certain aspects of inflammation and thin mucus. Few known adverse effects are associated with these enzymes, especially if taken via the buccal route. The buccal route is the preferred route because enzymes are inactivated by stomach acid and, even when taken on an empty stomach, maximum absorption is less than 40%. One buccal tablet is Clear Ease, which contains one million enzyme units of bromelain (from pineapple) and one half million enzyme units of papain (from papaya).

    • Iodides: Potassium iodide is a useful mucolytic medication.

    • Saline sprays: These can help keep the nose moist and thin the mucus. Using preparations without benzalkonium or thimerosal is important. Some of the spray bottles can be used for mist or for stream, which is useful when removing heavy dust or perfume from the nose is necessary. In 1999, Boek recommended Locke-Ringer solution as being superior to regular isotonic sodium chloride solution. Hypertonic sodium chloride solution may be of advantage in swollen turbinates, but patients have difficulty in using this.

  • Decongestants: Pseudoephedrine (Sudafed) has long been a favorite to open a stuffy nose. It is contraindicated in hypertension and in persons who are kept awake by the drug. Strangely, this drug may make children younger than 12 years drowsy. Spray decongestants include the following:

     

    • The effects of oxymetazoline last longer than the effects of neo-synephrine. Privine may cause drowsiness. For many years, Afrin was thought to cause rhinitis medicamentosum by shrinking the nose and then having rebound swelling. Today, the rebound addiction is thought to be caused by the benzalkonium; oxymetazoline is available without benzalkonium. One product is Natru Vent nasal decongestant.

    • Ipratropium bromide (Atrovent) is an acetylcholine blocker generally used as a bronchial dilator in the lungs but now used as a nasal spray.

    • Azelastine HCl (Astelin) is an antihistamine in spray form. This drug is excellent when steroid sprays are contraindicated. Many patients dislike the taste. A solution of Benadryl 25 mg added to one ounce of Locke-Ringer or sodium chloride solution can be made and yields similar results. The dose of the Benadryl must be titrated to the individual patient.

    • Cromolyn (Nasalcrom) nasal spray is highly effective for allergies if started 6 weeks before the pollen count gets high. Pollen calendars are available on the Internet (eg, AllergyBuyersClub.com)
  • Topical medications

     

    • Various moisturizing ointments are available to moisturize the nose, including AYR gel.

    • Topical antibiotics are useful in the nose and sinus. Neosporin ointment may be used for mild local infection. Bactroban ointment has been used extensively as a topical antibiotic with no reported adverse effects. This ointment can be added to Locke-Ringer or sodium chloride solution as a spray.

    • Gentamicin and tobramycin are used for irrigation (Davidson, 1995). Gentamicin has the advantage of being inexpensive; 40 mg can be added to 200 mL of Locke-Ringer or sodium chloride solution for irrigation with a pulsatile irrigation device. This can be used twice daily for advanced infection or once daily for milder chronic cases. Singulair taken orally or dissolved in Locke-Ringer or sodium chloride solution has been reported to be of particular value in vasomotor rhinitis.

    • Example of local irrigation is as follows: For topical irrigation with gentamicin or tobramycin, add 1 teaspoon of Breathe Ease or salt to 1 pint of water in irrigator basin. Irrigate until clear. Blow nose gently until clear. Adjust solution to contain 200 mL of solution and add 40 mg of gentamicin or tobramycin. Irrigate with full amount. Do not blow the nose. Use twice daily in the heavy purulent stage and then once daily during the clearing stage. Average treatment duration is 3 weeks.

  • Organisms and generally used antibiotics

     

    • Pneumococcus infections: Use penicillins, amoxicillin, erythromycin, and cephalosporins.

    • H influenzae: Use amoxicillin or amoxicillin with potassium clavulanate (Augmentin); macrolides such as erythromycin plus sulfasoxazole (Pediazole); cefuroxime (Ceftin); and trimethoprim and sulfamethoxazole (Septra, Bactrim).

    • Staphylococcal infections: Use amoxicillin plus potassium clavulanate (Augmentin), erythromycin, and dicloxacillin.

    • Pseudomonas infections: Use aminoglycosides, ciprofloxacin, and ofloxacin.

  • General classification of antibiotics

     

    • Antimicrobials such as penicillin G and V are bacteriocidal because they inhibit cell wall synthesis.

    • Antistaphylococcic penicillins include dicloxacillin (Dynapen).

    • Amino-penicillins include ampicillin and amoxicillin.

    • Augmented penicillins include amoxicillin plus potassium clavulanate (Augmentin).

    • Antipseudomonal penicillins include ticarcillin and carbenicillin, which are for IV use.

    • Cephalosporins are bacteriocidal (they inhibit cell wall synthesis). First-generation cephalosporins include cefazolin and Ancef for IV administration and cephalexin, cefadroxil, Duricef, and Keflex. Second-generation cephalosporins include cefuroxime (Ceftin) and cefaclor (Ceclor). Second-generation equivalents include loracarbef (Lorabid). Third-generation cephalosporins include cefixime (Suprax).

    • Macrolides include erythromycins, clarithromycin, and azithromycin.

    • Clindamycins include Cleocin and Lincocin.

    • Tetracyclines inhibit protein synthesis. Bacteriostatic tetracyclines include minocycline and Vibramycin.

    • Aminoglycosides can be ototoxic, are bacteriostatic, and inhibit synthesis. They include streptomycin, neomycin, gentamicin, tobramycin, and amikacin.

    • Quinolones include ciprofloxacin (Cipro) and ofloxacin (Floxin).

    • Sulfonamides are bacteriostatic but, when used with other antibiotics, are synergistic.

    • Trimethoprim and sulfamethoxazole include Septra and Bactrim.

    • Antifungal medications include amphotericin B, ketoconazole, and fluconazole (Diflucan).

    • Antiviral medications include acyclovir (Zovirax) and amantadine (Symmetrel).
  • Irrigation/aspiration: Clearing sinus infection is indicated for the individual with asthma. Irrigation/aspiration at the first office visit is a useful step in order to reduce the bacterial load. When the sinus infection does not clear with antibiotics, prescribe daily irrigation, mucolytics, and anti-inflammatory medications. Follow with a CT scan of the sinuses.
  • Pediatric treatment
    • Sinusitis and asthma occur in younger children (see Image 5). One useful technique for treating sinusitis in children is Proetz sinus irrigation, which is performed by placing the child hyperextended over the parent's lap so that the child's head is lowered. Ideally, the child's chin and ear are in a straight line perpendicular to the floor. The child's vasoconstrictor (eg, 1/8% Neo-Synephrine) is placed in both nostrils. Fill both sides with modified Locke-Ringer solution (Breathe Ease) or sodium chloride solution. Take care not to get into the eyes. Gently aspirate with a nasal aspirator. Keep refilling both sides with solution until the return is clear. This works better if the child cries. By removing this pus, the chance of developing a chronic sinus condition with an asthmatic sequel is diminished.

    • Nasal moisturizer spray is also of benefit to young children. Breathe Ease is specially designed to be used by small hands and contains a modified Locke-Ringer solution without benzalkonium. This does not sting or burn and is used by most children as a nasal spray. (The spray can be made more attractive to children, for example, by placing a sticker of the child's hero on the spray bottle.) Or isotonic sodium chloride solution can be prepared without preservatives. One half teaspoon of salt to 8 ounces of water makes an isotonic solution. Because no preservatives are added, the solution should be changed weekly.

    • Caution: When daily use of nasal spray for children occurs, pay particular attention to preservatives such as Thimerosal. The Academy of Pediatrics has recommended against its use, but it is still contained in certain nose drops. If the product is used long term, consider checking for mercury levels. Benzalkonium, another preservative, burns and stings and discourages the child from using the spray.

Surgical Care: Sinusitis may require surgical care. Primarily, the disease is a matter of obstruction of sinus drainage. If sterile cotton is placed in the healthy nose, whichever sinus is blocked becomes purulent. This is because the blockage prevents drainage along the mucociliary pathways, macrophages do not have access to the area, and bacteria are free to multiply. Surgery is directed at making sinus drainage adequate and effective.

The advances in FESS surgery make it easier and safer to clear the source of sinus disease. Insta-Trak delivers a 3-dimensional picture to the operator of the position of the instrument while the operator is performing surgery. This increases surgical success and reduces risk. A full CT scan of the sinuses is taken preoperatively. Metal markers are fixed on the patient and kept for surgery. At surgery, the same markers are placed in the designated areas. A magnet is placed on the suction. A screen shows the sinuses in 3 views. The device is used to visualize the position of the magnet in the 3 views at all times, thereby reducing the complication rate (see InstaTrak Image-Guided Surgery ).

  • Maxillary sinus

     

    • Blockage of the natural ostia can be caused by a foreign body. A deviated septum may compress this area. Hypertrophy of turbinates may be sufficient to block the opening. Concha bullosa refers to a hollow enlargement of the middle turbinate so that it blocks drainage of the maxillary ostia (see Image 6). More commonly, mucosal hypertrophy blocks the ostia. Over time, the maxillary sinus shows a worsening of the disease process. An aberrant air cell of the ethmoid may obstruct the maxillary sinus opening. Nasal polyps may develop in the opening itself or grow from a distal origin and be positioned to obstruct the ostia (see Image 7).

    • Treatment is directed to ensure sinus patency and to remove obstructive septum, polyps, and tissue. At surgery, obstruction to drainage is removed and instruments can enter the sinus cavity to remove diseased tissue. When patients report pain in the cheek and upper teeth, remember that the same nerve innervates the maxillary antrum and the upper teeth and that differentiation of the source of the pain is between dental and sinus origin.
  • Ethmoid sinuses

     

    • Ethmoid sinuses open into the middle meatus and the superior meatus. The same factors as above are involved (ie, polyps, turbinate hypertrophy, mucosal hypertrophy, septal deviation).

    • With the ethmoid sinuses, removing all diseased tissue, as well as obstructive conditions, is important. The ethmoid sinuses may cause infection into the globe of the eye. If the eye is swollen, consider obstruction of the ethmoid sinuses. Patients show puffy eyes, black eyes, and obstruction to breathing.
  • Sphenoid sinuses: Symptoms with the sphenoid sinuses are more diffuse and may manifest only as a headache and continued fever. Endoscopic examination shows obstruction to the opening of the sphenoid sinus, which must be cleared. CT scans are vital to evaluate the mucosa and the position of the sinus itself in relation to the brain and optic system. Normally, the right and left sphenoids are highly variable, and missing the wall of the opposite sinus as it deviates far to the opposite side is an easy error to make. In a patient with vague pain, elevated white count, and no signs of sinusitis on examination, endoscopic evaluation and CT scan may be the only means of diagnosing sphenoid sinusitis.
  • Frontal sinus

     

    • In addition to the usual causes of sinus obstruction, another factor adds to mucosal thickening, polyps, and anatomic obstruction. Following FESS surgery, during which the attachment to the lateral nasal wall may be compromised by removal of turbinate attachment at the sinus ostia, the middle turbinate may dislodge, swing forward, and obstruct frontal drainage.

    • Surgery consists of opening drainage channels. The frontal sinus drainage channel is somewhat long and obstruction can easily occur. Importantly, watch for severe pain or change in pain in the frontal area. An abscess may weaken or open the posterior wall into the skull cavity with serious effect. In such cases, immediate surgical correction is needed. Palpation of the floor of the frontal sinus may be diagnostic.
  • Chronic frontal area pain: Often, patients report pain in the frontal sinus area without fever or purulent nasal discharge for weeks or months. This pain usually is of cervical origin, characterized by painful cervical muscle areas posteriorly that refer pain to the frontal area (course of V1). Palpating the cervical area is helpful; look for trigger points and areas of referral to the frontal area. Less commonly, the pain can refer to the maxillary area (V2).
  • Removal of excess mucosa

     

    • A serious complication occurs following nasal and/or sinus surgery when excess mucosa is removed as in complete turbinectomy. Here, the nose may appear wide open yet the patient reports pain on breathing, burning, and not getting enough air.

    • Once large amounts of turbinate tissue have been removed, atrophic rhinitis with crusting takes place and requires frequent moisturizing. These patients are highly symptomatic because of the absence of normal nasal tissue that moisturizes and filters. Some of these patients have disabled nasal function because of the dryness, crusting, and discomfort. This has a serious effect on the lower respiratory system that is now breathing dry unfiltered air.
  • Hypertrophied turbinates
    • Hypertrophied turbinates may be the sole cause of nasal obstruction and frequent infections (see Image 9). These can be reduced safely by submucous resection of the turbinates. Make an incision inferiorly that is three fourths the length of the turbinate. Elevate the mucosa from the bone medially and laterally. Remove the bone, allowing the turbinate to move medially. Sutures are not usually placed. In healing, much of the submucosal blood vessels are reduced. Here, the mucosa is spared.
    • Another technique is radiofrequency therapy. One such device is the somnoplasty turbinate instrument. Here, the instrument is inserted submucosally, and the radiofrequency spares the mucosa. This is an office procedure but may require more than one sitting.
  • Removal of turbinates: Whichever technique is used in sinus and turbinate surgery, emphasis must be on preservation of nasal mucosa. Once the inferior and middle turbinates are removed, the patient has little defense to prevent chronic sinusitis. These patients have severe symptoms, and the lower respiratory system may be adversely affected as well.

Consultations: When the patient has frequently not responded to antibiotic treatment and other measures, consultation with an otolaryngologist is indicated. When good treatment is unsuccessful, frequently, an anatomic defect with obstruction of drainage is found. A limited CT scan showing blockage of the maxillary sinus requires a consultation with an otolaryngologist.

  • If allergy management does not improve nasal or chest breathing, consult with an otolaryngologist. Usually, findings are a severely hypertrophied turbinate that requires surgical attention or a sinus blockage, which may be the cause of treatment failure.
  • When treatment is consistently unsuccessful, consult with a hematologist or immunologist to rule out hematologic diseases and AIDS. Disorder of the globulin factors may be the cause.
  • When no obvious anatomic defect is present, yet infection defies treatment, check the hospital culture resistance and sensitivities. Local bacteria may be highly resistant to the antibiotic presently administered, and change can be guided by reviewing common hospital growths and resistance. Sometimes, referral to an infectious disease specialist is needed. Irrigation to restore cilia action is important regardless of what antibiotic is used.
  • Keep in mind that recurrent sinus infection (eg, 4 infections in 5 mo) is most likely the same infection that never cleared in the first place. When the sinus infection involves bone, consider intravenous treatment with appropriate medications. Some stubborn bacterial infections respond to hyperbaric treatments. Expect serous otitis when treating sinusitis with hyperbaric oxygen.
  • Candidiasis and mold infection, which may occur in individuals with immune suppression, can be observed with the naked eye as a characteristically snowy white presence on MRI. Often associated with polyps, candidiasis and mold infection have very poor response to antifungal medications. Surgery and medications are needed. Another form of candidiasis is observed in cases of chronic sinusitis. Here, the fungus normally present elicits an eosinophilic response, resulting in release of eosinophilic toxic products that cause illness and poor response to sinus management. Local irrigation with antifungal medications may help. Other treatments being tried are fungal desensitization.

Diet: One of the common urban myths is that milk makes mucus. Of course, certain persons may be allergic to milk, but the popular belief that avoiding milk prevents sinusitis is a myth. On the other hand, it seems to be the kind of information that sells popular books.

  • Hot tea: For singers, actors, and speakers, emphasize that hot tea with lemon and honey helps thin mucus and move the cilia; this treatment is especially recommended before a performance. Adequate hydration not only helps the sinus and chest, it can also reduce nosebleeds that many performers get when traveling or in desert climates.
  • Iced drinks: Iced drinks make the allergy worse and slow the cilia. Many allergy symptoms can be reduced by avoiding iced drinks and avoiding getting chilled.
  • Breakfast in bed: The individual with allergies warms the body by the actions of sneezing, hacking, and coughing. These actions do work to warm the body, but they start the cascade of symptoms of allergy. Often, 50% of these symptoms can be avoided by drinking a hot drink (eg, tea) before getting out of bed. Use a thermos or automatic percolator for the hot drink and eat a cookie or whatever else is desired. Afterwards, when the blankets are removed and the feet touch the cold floor, the body is already warmed and the coughing and sneezing are not necessary to warm the body. In addition, because of the tea stimulating the cilia, the dust that accumulated in the nose is removed and sneezing for dust removal is unnecessary. (Incidentally, each night the hotels in China provide their guests with hot tea in a thermos.)

Activity: For chest problems and postural drainage, breathing exercises are important. With shallow breathing, mucus can be trapped in distal tubules and generate bacterial infection. Stress deep breathing to remove distal air.

  • For exhaustion stage of allergy, when all treatments seem to have failed, simply going to full bed rest replenishes the body's cortisone level and often cures the symptoms.
  • In acute sinusitis, resting in bed and avoiding getting chilled are important parts of the therapy.

  MEDICATION  

Asthmatic treatment requires combinations of smooth muscle relaxants, bronchodilators, and anti-inflammatory medications. Because asthma is considered an inflammatory condition, antibiotics may be required as well. Sinusitis requires drainage of the infection, encouragement of mucociliary flow, and usually, antibiotics. Often, both asthma and sinusitis are treated simultaneously. Remember that what affects the sinus or chest affects the entire upper respiratory system.
 

Drug Category: Short-acting beta2-adrenergic agonists -- Often for daily and acute use. Rapid action on smooth muscles in bronchi. For onset of asthma and for exercise induced asthma. Abbreviations include the following: MDI metered dose inhaler, EIA exercise induced asthma, CDN compressor type nebulizer, DPI dry powder inhaler, and HFA Hydrofluoroalkane (ozone friendly propellent). Note: Holding chambers and spacers are terms used interchangeably.

Drug Name
 
Albuterol (Proventil, Ventolin) -- Beta-agonist for bronchospasm. Relaxes bronchial smooth muscle by action on beta2 receptors with little effect on cardiac muscle contractility.
Available as inhaler or as tab. Inhaler used for acute episodes of bronchospasm or for prevention of bronchospasm. For EIA. Other drugs in this class include bitolterol (Tornalate), levalbuterol (Xopenex), metaproterenol (Alupent), pirbuterol (Maxair), and terbutaline (Brethaire, Brethine, Bricanyl).
Adult Dose MDI: 2 puffs q4-6h; not to exceed 12 inhalations/d
DPI: 1 cap q4-6h
CDN: 2.5 mg tid/qid
Syr: 5-10 mL q6h
Pediatric Dose <4 years: Not established
>4 years:
MDI: 2 puffs qid
DPI: 1 cap q4-6h
Syr: 5 mL q6h
Contraindications Documented hypersensitivity
Interactions Beta-adrenergic blockers antagonize effects; inhaled ipratropium may increase duration of bronchodilatation by albuterol; cardiovascular effects may increase with MAOIs, inhaled anesthetics, TCAs, and sympathomimetic agents
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Caution in hyperthyroidism, diabetes mellitus, convulsive disorders, and cardiovascular disorders; tachycardia, smooth muscle tremor, hypokalemia, and increased lactic acid may occur; beta-receptor blockers inhibit albuterol action; large IV albuterol doses may aggravate preexisting diabetes mellitus
Drug Name
 
Metaproterenol (Alupent) -- Bronchodilator administered by inhalation. Rapid onset of action. Activates adenyl cyclase. Potent beta-adrenergic stimulator. Has preferential effect on beta2-adrenergic receptors compared to isoproterenol. For asthma and bronchial spasm of bronchitis and emphysema.
Aerosol contains 150 mg of metaproterenol for inhalation. Available as inhaler, solution for inhalation, syr, and as 10- or 20-mg tab.
Adult Dose MDI: 1-3 puffs initial; repeat in 3 h; total dose is 12 times q24h; delivers 0.65 mg of metaproterenol sulphate; can be used with a positive pressure device
Tab: 20 mg PO tid
Pediatric Dose 6-9 years: 5 mL syr PO tid/qid
>9 years: 10 mL syr PO tid/qid
Tab: 10 mg PO tid
Nebulizer (6-12 y): 0.1 mL single dose of 5% sol
Contraindications Documented hypersensitivity; cardiac arrhythmias or tachycardias
Interactions Beta-adrenergic blockers antagonize effects; cardiovascular effects may increase with MAOIs, inhaled anesthetics, tricyclic antidepressants, and sympathomimetic agents
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Titrate dose; caution in hyperthyroidism, diabetes mellitus, and cardiovascular disorders; decreased serum potassium may occur
Drug Category: Anticholinergic agents -- The parasympatholytic inhalers inhibit vagally mediated reflexes by antagonizing the action of acetylcholine released by the vagus nerve. This prevents the increase in intracellular concentration of cyclic guanosine monophosphate (GMP) caused by interaction of acetylcholine and muscarinic receptor on bronchial smooth muscle.
Help reduce mucus in the lungs. Relax the smooth muscles of the large and medium bronchi. May be used with short-acting beta2-adrenergic bronchodilators (eg, albuterol).
Drug Name
 
Ipratropium (Atrovent) -- Chemically related to atropine. Has antisecretory properties, and when applied locally, inhibits secretions from serous and seromucous glands lining the nasal mucosa. Site-specific effect, not systemic. Not used PO.
Also available as combination product with albuterol (Combivent).
Adult Dose MDI: 18 mcg/puff; 2-3 puffs q6h; not to exceed 12 inhalations/d
CDN: 1 vial q6-8h
Pediatric Dose Not established
Contraindications Documented hypersensitivity
Interactions Drugs with anticholinergic properties (eg, dronabinol) may increase toxicity; albuterol may increase effects
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Not indicated for acute episodes of bronchospasm; caution in narrow-angle glaucoma, prostatic hypertrophy, and bladder neck obstruction;
temporary blurring of vision may occur because of anticholinergic effects
Drug Category: Corticosteroids, inhaled -- From the cortex of the adrenal glands comes one of the more common classes of drugs used in cases of sinusitis and asthma. This class was discovered and named by Hans Selye while working with stressed rats. Selye described the action and named the chemical before the drug was actually identified. His work stimulated the search for and identification of corticosteroids. For asthma, these drugs (1) decrease inflammation and swelling in the airways, lessening airway hyperreactivity; (2) reduce the release of body chemicals from certain inflammatory cells; and (3) increase the effect of bronchodilator medications.
Drug Name
 
Beclomethasone (Beclovent, Vanceril, QVAR-HFA) -- Inhibits bronchoconstriction mechanisms and produces direct smooth muscle relaxation. May decrease number and activity of inflammatory cells, in turn decreasing airway hyper-responsiveness.
Various dose preparations are available and must be titrated in conjunction with other medications patient is taking; most inhaled PO medications have effect in 24 h.
Other drugs in this category include beclomethasone (Beclovent), budesonide (Pulmicort, Turbuhaler), flunisolide (AeroBid, AeroBid M), fluticasone (Flovent), and triamcinolone (Azmacort).
Adult Dose 42 mcg: 4-12 puffs/d up to 20 puffs/d
Pediatric Dose 42 mcg: 2-8 puffs/d up to 16 puffs/d
Contraindications Documented hypersensitivity; bronchospasm; status asthmaticus; other types of acute episodes of asthma
Interactions Coadministration with ketoconazole may increase plasma levels but does not appear to be clinically significant
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Caution in diabetes mellitus, glaucoma, ulcerative intestinal conditions, and pregnancy; weight gain, increased bruising, cushingoid features, acneiform lesions, mental disturbances, and cataracts may occur (taper medication slowly if these changes occur)
Drug Category: Corticosteroids, systemic -- Oral steroids are administered as a short-term burst or as routine maintenance therapy. Prednisone or methylprednisolone are recommended because they are short acting and reliably well absorbed and available to the lungs.
Drug Name
 
Prednisone (Deltasone) -- Glucosteroid that occurs naturally and synthetically. Used for both acute and chronic asthma. May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.
Loading or initial dose should be taken all at once in the am; may suppress natural cortisone production; hence, requires tapering the dose upon discontinuation.
As soon as the dose for relief is found, a maintenance dose may be established until the nonsteroidal drugs are effective; must always use a decreasing dose to avoid serious renal suppression.
For nasal polyps, the above dose should be combined with an antibiotic because the stasis of the polyp generally produces localized bacterial infection.
In seasonal allergy a booster of prednisone may speed resolution of symptoms. Quite effective in exhaustion stage of seasonal allergy.
Other drugs in this category include methylprednisolone (Medrol) and
prednisolone (Delta-Cortef, Pediapred, Prelone).
Adult Dose Allergic rhinitis: 5 mg number 21 PO; prescribed in diminishing doses: 6 tab day 1, 5 tab day 2, and so on to 1 tab the 6th d; all should be taken at once and not spaced out
Other programs: Up to 60 mg qd or every other dose to control symptoms or 40-60 mg for 3-10 d
Pediatric Dose 0.25-2 mg/kg qd or q2d
Contraindications Documented hypersensitivity; viral infection; peptic ulcer disease; hepatic dysfunction; connective tissue infections; fungal or tubercular skin infections; GI disease
Interactions Coadministration with estrogens may decrease prednisone clearance; concurrent use with digoxin may cause digitalis toxicity secondary to hypokalemia; phenobarbital, phenytoin, and rifampin may increase metabolism of glucocorticoids (consider increasing maintenance dose); monitor for hypokalemia with coadministration of diuretics
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Abrupt discontinuation of glucocorticoids may cause adrenal crisis; thinning of bones (ie, osteoporosis, which may lead to fractures or compressions, especially of the vertebral bones, ie, backbone), loss of blood supply to bones (ie, aseptic necrosis, which may cause severe bone pain and may require surgical correction), hypertension, glaucoma, cataracts, weight gain with increased appetite, fluid retention and stretch marks, facial fullness, increase in body hair and acne, easy bruising and thinning of the skin, along with poor wound healing, interference with growth in children, muscle weakness or cramps, joint pain, changes in menstrual cycle, diabetes mellitus, suppression of the body's adrenal gland (which makes necessary the amount of cortisol at times of stress, ie, adrenal insufficiency, adrenal gland function usually resumes when steroids are stopped or when they are taken in a single am or pm dose qod), irritability, depression, euphoria, or hallucinations may occur with glucocorticoid use
Drug Category: Methylxanthines -- Oral theophylline is an old standby related to caffeine. Not as popular now with the availability of more specific medications with fewer adverse effects. Can be used in combination with inhaled corticosteroids. Long duration of action makes it useful for nighttime asthma. Not recommended as a rescue medication.
Drug Name
 
Theophylline (Uni-Dur, Uniphyl, Theo-Dur, Theo 24, Slo-bid, Gyrocaps) -- Potentiates exogenous catecholamines, stimulates endogenous catecholamine release, and diaphragmatic muscular relaxation, which in turn stimulates bronchodilation. Generally added in order to reduce corticosteroid dosage.
For bronchodilation, near toxic (>20 mg/dL) levels are usually required.
Adult Dose 10 mg/kg initial; titrate up to 800 mg/d
Pediatric Dose 10 mg/kg/d initial; titrate
<1 year: Not to exceed 5 mg/kg/d
>1 year: Not to exceed 16 mg/kg/d
Contraindications Documented hypersensitivity; uncontrolled arrhythmias; peptic ulcers; hyperthyroidism; uncontrolled seizure disorders
Interactions Aminoglutethimide, barbiturates, carbamazepine, ketoconazole, loop diuretics, charcoal, hydantoins, phenobarbital, phenytoin, rifampin, isoniazid, and sympathomimetics may decrease effects of theophylline; theophylline effects may increase with allopurinol, beta-blockers, ciprofloxacin, corticosteroids, disulfiram, quinolones, thyroid hormones, ephedrine, carbamazepine, cimetidine, erythromycin, macrolides, propranolol, and interferon
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Caution in peptic ulcer, hypertension, tachyarrhythmias, hyperthyroidism, and compromised cardiac function; not to inject IV solution >25 mg/min; patients with pulmonary edema or liver dysfunction are at greater risk of toxicity because of reduced drug clearance; may cause nausea, vomiting, cramps, diarrhea, and tremors; may affect school performance
Drug Category: Leukotriene modifiers -- Can reduce the intake of inhaled corticosteroids. May be beneficial in difficult asthma cases. Begin to work in several hours but require up to a week for full effect.
Leukotrienes are one of the products released in asthma attacks that causes bronchoconstriction and inflammatory response as well as increased mucus production. Currently available in tab form, but being researched as a topical medication for the nose in spray form.
Drug Name
 
Montelukast (Singular), Zafirlukast (Accolate), Zileuton (Zyflo) -- Inhibit the cysteinyl leukotriene. Leukotrienes are products of arachidonic acid from mast cells and eosinophiles. They cause bronchial edema, smooth muscle contraction, and inflammation. A selective binding to the receptor occurs preventing this reaction. Zafirlukast and montelukast selectively prevent the action of leukotrienes released by mast cells and eosinophils. Zileuton inhibits leukotriene formation, which in turn decreases neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, capillary permeability, and smooth muscle contractions. Indicated for the prevention and maintenance of asthma.
Adult Dose Montelukast: 10 mg PO hs
Zafirlukast (Accolate): 20 mg PO bid
Zileuton (Zyflo): 600 mg PO qid
Pediatric Dose Montelukast:
2-5 years: 4 mg chewable PO hs
6-14 years: 5 mg chewable PO hs
Zafirlukast:
<12 years: Not established
>12 years: Administer as in adults
Zileuton: Not established
Contraindications Documented hypersensitivity
Interactions Montelukast: Phenobarbital and rifampin reduce effects
Zafirlukast: Erythromycin and theophylline decrease serum levels of zafirlukast; aspirin increases levels of zafirlukast; zafirlukast increases toxicity of warfarin
Zileuton: Increases the toxicity of propranolol, warfarin, and theophylline
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Not indicated to reverse acute asthma attacks; not for use as monotherapy in the management of exercise-induced bronchospasm; with zileuton, caution in liver disease
Drug Category: Mast cell stabilizers -- Especially effective for allergy but must be started weeks before exposure or pollen season, minimum one week. Inhibit sensitized mast cell degeneration when exposed to specific antigens by inhibiting the release of mediators from the mast cells. Block calcium ions from entering the mast cell. Inhibits immediate and nonimmediate bronchoconstriction. Has no direct action on bronchi.
Drug Name
 
Cromolyn sodium (Intal, Nasalcrom) -- Inhibits degranulation of sensitized mast cells following exposure to specific antigens. Recommended for prevention of cold- and exercise-induced asthma. May be effective in persons exposed to fumes (eg, smog, ozone, sulfur dioxide). Takes weeks to reach full effectiveness. Not recommended to treat an acute attack.
Helps when exposure to asthma triggers is unavoidable. Useful for pet exposure or occasional horse exposure.
Adult Dose MDI: 2 puffs qid
Nasal spray: 1 spray qid
Pediatric Dose MDI: 1-2 puffs qid or prn
Contraindications Documented hypersensitivity
Interactions None reported
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions May induce bronchospasm; not for use in severe renal or hepatic impairment; symptoms may reoccur when withdrawing drug; adverse effects include throat irritation, dryness, bad taste, wheezing, and nausea
Drug Category: Antibiotics -- Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting. Most common organisms are S pneumoniae, H influenzae, and M catarrhalis.
Drug Name
 
Amoxicillin (Amoxil, Trimox) or amoxicillin with clavulanate (Augmentin) -- Interferes with synthesis of cell wall mucopeptides during active multiplication resulting in bactericidal activity against susceptible bacteria.
Clavulanate increases activity of beta-lactam antibiotics in resistant bacteria.
Adult Dose Amoxicillin: 500 mg PO tid
Amoxicillin and clavulanate: 400-500 mg PO tid
Pediatric Dose Not established
Contraindications Documented hypersensitivity
Interactions Reduces efficacy of PO contraceptives; coadministration with warfarin or heparin increases risk of bleeding
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Adjust dose in renal impairment
Drug Name
 
Trimethoprim and sulfamethoxazole (Bactrim, Septra DS) -- Inhibits bacterial growth by inhibiting synthesis of dihydrofolic acid.
Adult Dose 160 mg TMP/800 mg SMZ PO q12h
Pediatric Dose <2 months: Not recommended
>2 months: Not established
Contraindications Documented hypersensitivity; megaloblastic anemia due to folate deficiency
Interactions May increase PT when used with warfarin (perform coagulation tests and adjust dose accordingly); coadministration with dapsone may increase blood levels of both drugs; coadministration of diuretics increases incidence of thrombocytopenia purpura in elderly people; phenytoin levels may increase with coadministration; may potentiate effects of methotrexate in bone marrow depression; hypoglycemic response to sulfonylureas may increase with coadministration; may increase levels of zidovudine
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Discontinue at first appearance of skin rash or sign of adverse reaction; obtain CBCs frequently; discontinue therapy if significant hematologic changes occur; goiter, diuresis, and hypoglycemia may occur with sulfonamides; prolonged IV infusions or high doses may cause bone marrow depression (if signs occur, administer 5-15 mg/d leucovorin); caution in folate deficiency (eg, chronic alcoholism, old age, anticonvulsant therapy, malabsorption syndrome); hemolysis may occur in G-6-PD deficient individuals; AIDS patients may not tolerate or respond to TMP-SMZ; caution in renal or hepatic impairment (perform urinalyses and renal function tests during therapy); administer fluids to prevent crystalluria and stone formation
Drug Name
 
Clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin (EES) -- Inhibit bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes causing RNA-dependent protein synthesis to arrest.
Adult Dose Clarithromycin: 500 mg PO bid
Azithromycin: 500 mg PO on day 1, followed by 250 mg PO qd on days 2-5
Erythromycin: 250 mg erythromycin stearate/base (or 400 mg ethylsuccinate) q6h PO 1 h ac, or 500 mg q12h; alternatively, 333 mg q8h, increase to 4 g/d depending on severity of infection
Pediatric Dose Not established
Contraindications Documented hypersensitivity; hepatic impairment; coadministration with pimozide
Interactions Azithromycin: May increase toxicity of theophylline, warfarin, and digoxin; effects are reduced with coadministration of aluminum and/or magnesium antacids; nephrotoxicity and neurotoxicity may occur when coadministered with cyclosporine
Clarithromycin: Toxicity increases with coadministration of fluconazole, astemizole, and pimozide; clarithromycin effects decrease and GI adverse effects may increase with coadministration of rifabutin or rifampin; may increase toxicity of anticoagulants, cyclosporine, tacrolimus, digoxin, omeprazole, carbamazepine, ergot alkaloids, triazolam, and HMG CoA-reductase inhibitors; cardiac arrhythmias may occur with coadministration of cisapride; plasma levels of certain benzodiazepines may increase, prolonging CNS depression; arrhythmias and increase in QTc intervals occur with disopyramide; coadministration with omeprazole may increase plasma levels of both agents
Erythromycin: May increase toxicity of theophylline, digoxin, carbamazepine, and cyclosporine; may potentiate anticoagulant effects of warfarin; coadministration with lovastatin and simvastatin increases risk of rhabdomyolysis
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions May increase hepatic enzymes and cholestatic jaundice; caution in patients with impaired hepatic function, prolonged QT intervals, or pneumonia; caution in hospitalized, geriatric, or debilitated patients; diarrhea may be sign of pseudomembranous colitis; superinfections may occur with prolonged or repeated antibiotic therapies; coadministration of clarithromycin with ranitidine or bismuth citrate is not recommended with CrCl <25 mL/min; administer half dose or increase dosing interval if CrCl <30 mL/min
Drug Name
 
Cefaclor (Ceclor), cefuroxime (Ceftin), loracarbef (Lorabid) -- Second-generation cephalosporin maintains gram-positive activity that first-generation cephalosporins have. Adds activity against Proteus mirabilis, H influenzae, Escherichia coli, Klebsiella pneumoniae, and M catarrhalis.
Adult Dose Cefaclor: 500 mg PO tid
Cefuroxime: 250 mg PO bid
Loracarbef: 400 mg PO bid
Pediatric Dose Not established
Contraindications Documented hypersensitivity
Interactions Disulfiramlike reactions may occur when alcohol is consumed within 72 h after taking cefuroxime; may increase hypoprothrombinemic effects of anticoagulants; may increase nephrotoxicity in patient receiving potent diuretics (eg, loop diuretics); coadministration with aminoglycosides increases nephrotoxic potential
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Reduce dosage by one half if CrCl is 10-30 mL/min and by one fourth if <10 mL/min; bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy
Drug Name
 
Cefixime (Suprax) -- Third-generation cephalosporin. By binding to one or more of the penicillin-binding proteins it arrests bacterial cell wall synthesis and inhibits bacterial growth.
Adult Dose 400 mg/d PO qd
Pediatric Dose Not established
Contraindications Documented hypersensitivity
Interactions Coadministration of aminoglycosides increases nephrotoxicity; probenecid may increase effects of cefixime
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Adjust dose in renal impairment
Drug Name
 
Clindamycin (Cleocin) -- Inhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes causing RNA-dependent protein synthesis to arrest.
Adult Dose 150-300 mg PO q6h
Pediatric Dose Not established
Contraindications Documented hypersensitivity; regional enteritis; ulcerative colitis; hepatic impairment; antibiotic-associated colitis
Interactions Increases duration of neuromuscular blockade induced by tubocurarine and pancuronium; erythromycin may antagonize effects of clindamycin; antidiarrheals may delay absorption of clindamycin
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Adjust dose in severe hepatic dysfunction; no adjustment necessary in renal insufficiency; associated with severe and possibly fatal colitis
  FOLLOW-UP  

Further Inpatient Care:
 

  • After 1-2 years, if sinusitis symptoms persist (eg, congestion, drainage, fever, pain), a repeat of the CT scan may be indicated.
  • Following surgery, the patient may report not getting enough air, burning in the nose, and dryness. These symptoms often reflect poor cilia function. The nasal membranes appear dry and irritable, and they look thin. Even though the airway is wide open, these symptoms persist with poor cilia function. Treatment is hydration, nasal moisturizer sprays, and ointments. Pulsatile irrigation provides relief and helps restore cilia activity.
  • The complications following mid and inferior turbinectomy include loss of airway resistance and loss of olfactory, tactile, and temperature sensors (the empty nose syndrome). This may be observed after bilateral inferior and middle turbinectomy. Symptomatic relief can be offered by pulsatile irrigation with a Locke-Ringer solution such as Breathe Ease tid. In this condition, dryness and crusts are prominent. CT scanning shows mucosal thickening of the paranasal sinuses, loss of definition of the osteomeatal complex, and enlargement of the nasal cavity with destruction of the lateral nasal wall. The patients may be utterly miserable and report the following:
    • I can't breathe.

    • I can't smell things.

    • I can't get enough air.

    • My sleep is disturbed.

    • I'm plugged up.

    • I get frequent infections.

    • My ears feel plugged.
  • Determine if the symptoms have returned because the patient no longer keeps environmental precautions. When asthma persists, check for GERD
  • Determine if the polyps returned because the patient is taking salicylates.
  • Ask if the patient acquired a new pet.
  • The presence of thick phlegm breeds bacteria and keeps antigens in the system. Thick phlegm must be controlled with moisturizers and sufficient liquid and irrigation.

Further Outpatient Care:
 

  • If the cilia of the nose remain normal, few sinus infections should occur; therefore, efforts should be directed to keeping the cilia of the nose normal. Use Locke-Ringer or saline (without Benzalkonium) solution to ensure moisture of the nose. Stress hydration, especially the intake of hot tea and/or chicken soup. Warm compresses to the sinus area are important.
  • If sinus symptoms persist, review dust proofing of the bedroom with the patient.
  • If cilia of the nose remain slow as shown by dry irritable membranes and thick phlegm, consider pulsatile irrigation with Locke-Ringer or saline solution in order to restore cilia. If cilia are permanently damaged (eg, by excess removal of mucosa, chlorine gas, other toxic substances), consider pulsatile irrigation daily to keep nose moist and remove thick phlegm and materials.
  • Check for history of nasal polyps on an annual basis. Remind patients to avoid salicylates. Begin therapy if polyps are recurring.
  • On waking up in the morning, the dust has accumulated in the nose and the body temperature is low. If an individual throws off the covers and touches the cold floor with the feet, a cascade of sneezing and hacking warms the body and removes the dust; however, this is an undesirable method to warm the body. Drinking hot tea before getting out of bed avoids this morning cascade of sneezing and hacking.
  • Cold air and getting chilled can also trigger an asthma attack. Drinking hot tea before getting out of bed is an excellent preventative.
  • The speed of the nasal cilia often reflects the action of the chest cilia. In difficult asthma with associated coughing, determine whether the nasal cilia are inactive. Seek the cause. After exposure to chlorine, chromium, or aldehydes, if the nasal cilia are affected, so are the chest cilia. Ascertain a medication effect, eg, Benadryl and chlorpheniramine may slow nasal and chest cilia.

In/Out Patient Meds:
 

  • The continuous medication that is best for individual patients is variable. Pseudoephedrine with guaifenesin combinations is usually tolerated well and provides relief. Continued use of a corticosteroid spray may be indicated. Nonsteroidal sprays such as Astelin may provide nasal relief.
  • Long-term use of the corticosteroids, such as Flonase and Rhinocort Aqua, may provide symptomatic relief to many patients. Adverse effects of these and similar products include thinning of membranes and epistaxis. These effects do not appear until after at least 6 months of use and may be prevented by alternating with saline without benzalkonium or Breathe Ease moisturizer spray.
  • For patients who continue to catch common colds frequently with severe symptoms, daily pulsatile irrigation may be beneficial in reducing incidence of the common cold. Pulsation reduces the amount of intercellular adhesion molecule-1 (ICAM-1) on the nose. This is the channel for the common cold virus to enter the nose.
  • Hypertonic solutions may provide benefit for short periods when the nose is boggy and edematous. Usually these solutions irritate after a while. Try 2 tsp of salt to a pint of water or 2 tsp of Breathe Ease. Hypertonic solutions can be administered up to 3 times the normal dose (ie, 3 tsp salt to 1 pt of water). In 1999, Boek recommended Locke-Ringer solution instead of isotonic sodium solution. When this solution is made hypertonic (ie, 3 tsp Breathe Ease to 1 pt of water), less burning occurs because of the electrolyte balance. The author recommends adding the solutions to boiled or bottled water because many persons are sensitive to the chlorine in the public water supply.
  • Antihistamines in solution work for some patients. Astelin is a mixture of antihistamine for nasal use. An inexpensive mixture that patients can use is to dissolve Benadryl 50-mg capsule in an ounce of Breathe Ease or sodium chloride solution. The dose is variable, and patients do comment on the taste. Some patients do well with 100 mg of Benadryl to the 1 oz; therefore, have the patient titrate the dose.
  • Patients may continue to experience thick phlegm despite good surgery, pulsatile irrigation, and nasal moisturizers. Consider inhalant usage and investigate a food allergy. Try food elimination diets. Guaifenesin and proteolytic enzymes (eg, Clear Ease) are of help. Stress adequate fluid intake. If surgery has not been performed, thick nasal phlegm in the nose reflects similar phlegm in the chest, and efforts should be directed to thinning the phlegm. Thick phlegm in the chest can easily become infected. Stress liquids, breathing exercises, postural drainage, and steam inhalation. Steam inhalation for the chest is effective if the mouth is open and the tongue is extended.
  • In theory, vaporizers moisten the air and thin the mucus. In practice, they are difficult to keep clean and end up growing mold. Steam does not reach the lungs intact unless the tongue is extended. Steam in the shower is very good if the tongue is extended. For travelers, hang wet towels in the bedroom, set out pans of water (if available), and fill the bathtub with water and/or set the shower faucet to drip water.
  • Some patients become ill whenever taking an airplane flight. This can be a serious problem for the patient with a sinus/asthma condition. In theory (and in practice for this author's patients), placing an antibiotic ointment, such as Bactroban, in the nose may help by killing certain bacteria, forming a shield against the other passengers who cough and sneeze. Patients should avoid iced drinks and drink hot tea to improve cilia function.
  • As in any illness, anxiety can make the illness worse. Recommend some type of stress reduction technique to be part of the therapy. One method is to stand before the mirror with the chest exposed. Breathe in to the count of 4 and out to the count of 6. The exact time for each breath is not important as long as exhalation is longer than inhalation. Relax when exhaling. Visualize the face relaxing, the jaw relaxing, and the shoulders relaxing. The mirror serves as a type of biofeedback mechanism to tell patients when they are doing the stress reduction technique correctly. Instruct the patient to do this 10 minutes a day. With asthma or sinus attack, the complication of anxiety reinforcement is reduced. Stress reduction techniques are especially valuable for children.
  • Not every salt can be used to make a sodium chloride solution for irrigation. Regular salt contains silica and iodine. Some patients are sensitive to this. Sea salt is evaporated and contains various products; sea salt is high in iodine. These products can be irritating to the sensitive patient. Kosher salt or pickling salt is free of iodine and silica. Breathe Ease is based on the Locke-Ringer solution formula with sodium chloride, calcium chloride, potassium chloride, and sodium bicarbonate. This balance has been shown to be more effective for cilia than isotonic sodium chloride solution is.

Deterrence/Prevention:
 

  • Dust proofing is the best deterrence.

  • Hot tea thins thick mucus. Thick mucus must be thinned by a moisturizer or pulsatile irrigation or proteolytic enzymes taken buccally.
  • Elements of the workplace cause sinusitis and asthma. Certain chemicals are highly toxic to the cilia. These include chromium dust, sulfur dioxide, smog, ozone, and certain aldehydes (see Dr. Grossan The Ear, Nose & Throat On-line Consultant). For the individual with asthma, this may constitute a disability factor. (Discussion of workplace asthma by pulmonologist Larry Martin can be found at AllergyBuyersClub.com.)
  • For persons who frequently catch the common cold, Rabizza recommends daily irrigation to remove ICAM-1, which is the entrance factor for this virus.
  • For allergic nasal or chest symptoms, Naso Chrom started 6 weeks before pollen season often is effective.
  • Persons who experience burning or lack of benefit from prepared nasal moisturizers may be reacting to the preservatives (eg, benzalkonium). Switch to homemade products.

Complications:
 

  • Complications of sinusitis include the following:
    • Generalized infection due to circulatory dissemination of bacteria
    • Bronchial infection probably due to direct passage by infected mucus into the trachea: Bacteria in the sinus appear in the trachea 16 hours later.
    • Meningitis via venous and lymphatic drainage into the CNS or by direct extension through the posterior wall of the frontal sinus or throughout the olfactory area: Sometimes a fistula may be present after sinus surgery. If fever develops in a patient who has had sinus surgery, rule out meningitis and look for fistula, usually in or near the cribriform plate.
    • Cavernous sinus thrombosis: The cavernous sinus is a highly vascular area containing optic nerves and cranial nerves III, IV, and VI. It may arise from sphenoid sinusitis.
    • Optic spread: Spread can be via the ethmoid sinuses and can cause orbital cellulitis. Optic spread is more common in children than adults.
  • Asthma complications can be fatal and include the following:
    • Reduced oxygenation
    • Pneumonia
    • Emphysema

Prognosis:
 

  • Patients with sinusitis and asthma have a good prognosis. When the allergist and the ENT specialist are available for problems associated with these diseases, the prognosis is often satisfactory.
  • If the patient has experienced failure after sinus surgery, the prognosis is poorer. Factors such as regrowth of obstructing tissue, poor response to infection, and poor response to antibiotics suggest nonoptimum prognosis.
  • If the patient's course of sinusitis and asthma has been poor, review factors of immune response. Consider cystic fibrosis, GERD, HIV, and/or systemic infection.
  • Hypothyroidism is associated with allergy conditions. Often, specific allergy desensitization may initially be unsuccessful and then succeed when thyroid supplement is added.

Patient Education:
 

  • Patient education includes dust-proofing instructions. Encourage patients to keep the bedroom free of dust and mold (see Sinusitis: A Treatment Plan That Works for Asthma and Allergies Too for details).
  • Instruct patients to keep the nose moist with moisturizer.
  • Educate patients regarding importance of adequate hydration.
  • Instruct patients to keep windows of bedroom closed at 5 am and 5 pm. This is when the plants pollinate. Allergic patients do better when they have hot tea before getting out of bed in the morning.
  • Educate patients regarding the availability of pollen calendars (see AllergyBuyersClub.com). For allergy, if cromolyn nasal spray is started 6 weeks before the season, excellent results are possible.
  • Dogs, cats, and birds must be kept out of the bedroom.
  • Instruct patients to drive with car windows closed, especially in the late afternoon.
  • Teach adults and children to blow the nose gently with both sides open. Instruct patients how to clear the ears.
  • Educate patients about dust proofing the environment. Many allergy companies supply free booklets detailing the dust-proofing instructions. These should be a significant part of the armamentarium of treatment of sinusitis and asthma. Usually, during the third visit to the physician's office, the patient hears the instructions regarding dust proofing; after the fifth office visit, patients actually start the dust-proofing process. Make sure the instructions include no smoking. Repeat the instructions regarding dust proofing, daily breath exercises, and peak flow measurements with each patient visit to the office.

     
  • For excellent patient education resources, see eMedicine's Asthma Center and Headache Center. Also, visit eMedicine's patient education articles, Asthma, Asthma FAQs, Understanding Asthma Medications, and Sinus Infection.
  MISCELLANEOUS  

Medical/Legal Pitfalls:
 

  • Failure to diagnose pneumonia: One frequent pitfall involves the patient who is miserable with sinusitis and coughing. Whatever the medical specialty, the physician must listen to the chest and look for asthma, pneumonia, wheezing, and/or a silent lung. Just because sinusitis is present, the physician cannot assume that this is the only cause of the cough. One problem, of course, is that some ENT specialists are not expert at listening to the chest; however, the physician must listen and document that action. When in doubt, refer to a pulmonologist or an internist. Failure to recognize asthma or pneumonia in the presence of sinusitis is an area of litigation.
  • Cerebral spinal fluid fistula: The ENT surgeon works in the roof of the nose where the skull and contents are thinly separated (see Image 10). The CT scan must be in the operating room, and the surgeon must look for deep areas where the floor of the skull descends below ordinary areas. A dehiscence may already be present. Recognizing this complication is important. Look for signs of meningitis and unusual headache postoperatively. Sometimes these signs are masked by the antibiotics. A unilateral clear drainage following surgery carries a very high suspicion of a fistula. Laboratory tests are used to determine if this is cerebral spinal fluid. These fistulae can be closed via endoscopic route. The important thing is to make the proper diagnosis. Failure to make the diagnosis can lead to litigation.
  • Eye complications: Surgery on the ethmoid sinuses can lead to entrance into the globe of the eye. With the increased bleeding, this complication may not be recognized. Any visual disturbance or muscle paralysis postsurgery should suggest a surgical eye complication. Often these eye complications are difficult to repair.
  • Sphenoid sinus: The lateral walls of the sphenoid sinus contain the cavernous sinuses and the various ocular nerves. These areas are rarely compromised because normally the walls are thick.
  • Anosmia: Anosmia is not an infrequent complication. As soon as the instrument strays to the midline, the cribriform plate, which contains the olfactory nerve endings, can be affected. A frequent cause is septoplasty in which the bone is rocked by forceps. Rocking the bone in order to break it can easily move the ethmoid bone, thereby disrupting the olfactory nerves. Always use biting forceps in this area to prevent anosmia. This complication is not reparable.
  • Atrophic rhinitis: Postoperatively, the nose may look wide open; however, the patient is miserable, the nose is dry, and the normal functions of moistening the air, heating the air, and trapping bacteria in mucus are now gone because the mucosa of the turbinates have been removed. Turbinectomy, unless performed so as to preserve mucosa and function, can leave the patient highly symptomatic and ready to litigate. Prevention is to preserve turbinate mucosa. See empty nose syndrome.
  • Allergy: Failure to diagnose allergy may lead to litigation. The patient may be misdiagnosed with sinusitis. An excellent surgery is performed to straighten the septum and move the turbinates. Postoperatively, the patient still has nasal obstruction and the physician recommends a second operation. The patient goes to an allergist who clearly demonstrates a 4 plus dust allergy, and the patient's condition clears on desensitization. Now, the patient is ready to legally sue the surgeon because surgery was not necessary. Performing surgery with the knowledge that an allergy condition exists and explaining that the allergy condition will either persist or improve after surgery is not a problem; however, to not offer the patient the choice of allergy therapy versus surgery is a failure of good medicine.
  • Medications: The patient may be taking medicine from an orthopedist, an endocrinologist, a psychiatrist, and an internist. Because of drug interaction concerns, at times the otolaryngologist can only prescribe sodium chloride solution for the patient. Drug interaction is a serious problem and one that can easily lead to litigation. Somewhere in the literature the lawyer can find a case where one drug should not be administered with another drug. One defense is to insist that the patient only use a single pharmacist who, hopefully, looks at these interactions. Another is to speak with the internist or the hospital pharmacist.
  • Frontal sinusitis: Following endoscopic surgery, the attachment of the middle turbinate may move so as to block the frontal sinus. Look for this etiology when a history of prior endoscopic procedures is present. Even in this golden age of antibiotics, frontal sinus abscesses do occur. They may rupture through the posterior wall into the brain. The difficulty with this diagnosis comes with the patient who is seen weekly who has severe symptoms, including frontal headache. When a noncomplaining patient reports frontal pain, consider frontal sinusitis. A CT scan (not an MRI) must be obtained to evaluate the posterior wall of the frontal sinus.
  • Prednisone: Never refill prednisone. Good doctors do forgot to write "do not refill" on the prescriptions, and patients do keep refilling these prescriptions. Alternatively, the physician can refill a prescription by phone and not see that the patient has Cushing disease. Always write "do not refill" on prednisone and similar medications. Patients often feel great on prednisone and will think of ways to get more, including altering the prescription or calling the physician's associate or registered nurse.

  • The chart: One pitfall is a chart that does not adequately describe the lesion and does not include pictures or diagrams. At surgery, any description of the deviated septum is similarly absent in the chart. Include pictures, diagrams, and descriptions with documentation in the chart so a lawyer cannot claim that surgery was not indicated. Insurance carriers look for ways to avoid payments, and a chart without adequate documentation makes this easy for them.

  • Discussion of complications: Writing "complications were discussed" is acceptable, but the patient may still insist that no discussion occurred. In one such case, the office chart and hospital chart were complete and nicely written. Dictation regarding the surgery occurred right after the operation. The dictation was complete, and the important details were included. This case was easy to legally defend because any doctor with such thorough charts would obviously be just as thorough in explaining the complications.

  • Written instructions: For example, one patient puts the eardrops in the mouth; another patient puts the liquid penicillin in the nose and then claims that the physician verbally instructed that the penicillin was for the nose. Always assume the worst-case scenario and write the instructions separately from verbal instructions. Keep a copy of the written instructions.

  • Speaking the patient's language: Using terms and analogies that the patient really understands is necessary. Use pictures, diagrams, and other communication tools. Have the patient hold the skull while explaining the surgery.

  • Discussing the alternatives: The moment the doctor mentions surgery the patient may dismiss it as a possible treatment. Advise the patient of alternative care. Options include (1) continuing with medication, which has not worked; (2) trying 2 years of allergy shots; (3) trying more cortisone and risking the adverse effects; or (4) trying surgery. In a good practice, patients usually have already explored all options, so surgery is the remaining option.

  • Adequate medical course: The guidelines for ENT surgery are clear that the nonsurgical approach must be tried before surgery. Complications at sinus surgery do occur. A lawyer may argue that the CT scan showed thickened membranes. In other words, the lawyer is implying that the physician could have prescribed antibiotics and cleared the membranes without surgery. Another example is if the patient had polyps. A lawyer may quote a medical expert who says that a physician should always try medication to shrink the polyps. The lawyer then asks why this medication was not tried and implies that the physician was anxious to sell an operation. No matter what procedure is performed, some article can always be found that reports that the procedure either should not be performed or should be performed differently. Be aware of the other opinions in the medical field because the opposing attorney will be aware of these options.

  • Expecting the worst: From the author's experience, using diagrams, speaking clearly, and using words that the mother seemed to understand, this author explained the need for adenoidectomy and myringotomy for her child and then asked if she had any questions. An hour later, the mother's doctor called to report that the mother was in his office crying because nothing had been explained to her regarding surgery.

  • The “never operate” argument: A favorite legal ploy is reporting that the medical expert says never operate on patients with this condition. This quote may be taken out of context and may be taken from a medical journal written in a foreign language. Demand to see or read the entire article.
  PICTURES  

Caption: Picture 1. Asthma and sinusitis. Lateral sinus wall. Perform nasal endoscopy to reveal patent or closed sinus ostia. Look for purulent areas.
Click to see larger picture
Picture Type: Image
Caption: Picture 2. Asthma and sinusitis. Septal deviation with concha bullosa. On the CT scan, the bony anatomy, including the important structures of the maxillary frontal and sphenoid ostia, is detailed. The cribriform plate, whose anatomic position is a critical factor in any surgery, is visualized. The surgeon looks for depression at this area and dehiscence. In the image, the septum is deviated to the left, and the concha bullosa is right of the middle turbinate.
Click to see larger picture
Picture Type: Image
Caption: Picture 3. Asthma and sinusitis. Lateral wall anatomy, nasal endoscopy. Patent or closed sinus ostia may be revealed. The maxillary, frontal, and sphenoid ostia are visualized. Purulent discharge is noted.
Click to see larger picture
Picture Type: Image
Caption: Picture 4. Asthma and sinusitis. Hydro Pulse Irrigator. Because bacteria and thick phlegm play a significant role, the physician can reduce the asthmatic symptoms from sinusitis by suctioning or irrigating in the office if pus is present in the nose or sinuses. One technique is to use a vasoconstrictor in the nose, wait 2 minutes, and then irrigate with a modified Locke-Ringer solution or sodium chloride solution with a pulsatile nasal irrigator. Not only is a considerable amount of surface and sinus pus removed, but the pulsatile action at 20 pulses per second stimulates the cilia of the nose and sinuses to restore normal cilia action. Flow of solution past the orifice creates a Bernoulli effect to displace the sinus contents. The additional pulsation aids this process.
Click to see larger picture
Picture Type: Photo
Caption: Picture 5. Asthma and sinusitis. Radiograph of a child. Note the size of maxillary sinuses. Ethmoids are beginning to develop, but the frontal sinus is not yet present. One useful technique for treating sinusitis in children is Proetz sinus irrigation, which is performed with the child hyperextended over the parent's lap so that the child's head is lowered.
Click to see larger picture
Picture Type: X-RAY
Caption: Picture 6. Asthma and sinusitis. Concha bullosa. Blockage of the natural ostia can be caused by a foreign body. A deviated septum may compress this area. Hypertrophy of turbinates may be sufficient to block the opening. Concha bullosa refers to a hollow enlargement of the middle turbinate so that it blocks drainage of the maxillary ostia.
Click to see larger picture
Picture Type: Image
Caption: Picture 7. Asthma and sinusitis. Nasal polyps may develop in the opening itself or grow from a distal origin and be positioned to obstruct the ostia. Treatment is directed to ensure sinus patency and to remove obstructive septum, polyps, and tissue.
Click to see larger picture
Picture Type: Photo
Caption: Picture 8. Asthma and sinusitis. The most common ENT surgery is correction of a deviated septum. Because of multiple injuries, the septum is no longer in midline. When it blocks breathing (see Image 2), the entire airflow pattern can be upset, or the septum may impact solidly against the sides (septal spur) and cause blockage of drainage from sinuses.
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Picture Type: Image
Caption: Picture 9. Asthma and sinusitis. Hypertrophied turbinates may be the sole cause of nasal obstruction and frequent infections. These can be safely reduced by submucous resection of the turbinates.
Click to see larger picture
Picture Type: Image
Caption: Picture 10. Asthma and sinusitis. Cerebral spinal fluid fistula. The ENT surgeon works in the roof of the nose where the skull and contents are thinly separated.
Click to see larger picture
Picture Type: CT
  BIBLIOGRAPHY  

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