Asthma and SinusitisLast Updated: June
8, 2004 |
| Synonyms and related keywords:
respiratory distress, bronchitis, allergic bronchitis, sinus
problems, sinus infection, postnasal drip, rhinitis, allergic
rhinitis, mucociliary clearance, asthmatic, reactive airway disease,
wheeze, bronchiolitis, bronchial asthma, acute asthma, allergies,
bronchial airways, bronchial airway narrowing, inflammation of the
bronchi, bronchial smooth muscle contraction, wheezing, dyspnea,
airway narrowing, noisy breathing, difficult breathing, difficulty
breathing, respiratory disease |
| Author: Murray Grossan, MD, Consulting Staff,
Department of Otolaryngology, Cedars Sinai Hospital of Los Angeles
|
| Murray Grossan, MD, is a member of the following medical
societies: American Academy of Otolaryngology-Head and Neck Surgery
|
| Editor(s): Lanny Garth Close, MD, Chair,
Professor, Department of Otolaryngology-Head and Neck Surgery,
Columbia University College of Physicians and Surgeons;
Francisco Talavera, PharmD, PhD, Senior Pharmacy
Editor, Pharmacy, eMedicine; Stephen G Batuello,
MD, Assistant Professor, Department of Otolaryngology-Head
and Neck Surgery, The Medical Center of Aurora; Christopher
L Slack, MD, Consulting Staff, Otolaryngology-Facial
Plastic Surgery, Lawnwood Regional Medical Center; and Arlen
D Meyers, MD, MBA, Professor, Department of
Otolaryngology-Head and Neck Surgery, University of Colorado School
of Medicine |
Background: In the
United States, 35 million persons have sinus problems and 15 million
persons have asthma. Clinically, physicians know that a sinus infection
can contribute significantly to the frequency and severity of asthma
attacks. The purpose of this article is to outline the factors common to
both conditions and to note how best to improve these conditions.
Asthma and sinusitis both have been recognized in ancient literature.
In the 1940s and 1950s, considerable sinus surgery was performed to help
people with asthma. Purulent diseased tissue was removed, the nasal airway
was opened, and excellent results were achieved for some of these
patients. Then, in the 1960s, the improvements following sinus surgery
were thought to be related more to the stress reaction than to the
surgical technique; therefore, sinus surgery became less popular as a
principle of asthma management.
With the introduction of the CT scanning technique in the 1970s,
accurately pinpointing the location and extent of the sinus pathology
became possible. A return to corrective surgery for individuals with
sinusitis and individuals with asthma has occurred, thanks to the studies
of Rachelevsky, Spector, and many others showing the benefits of clearing
sinus pathology. Then, in the 1980s, functional endoscopic sinus surgery
(FESS) and the ability to physiologically improve sinus function became
available.
In the 1990s, as CT scanning has enhanced the view of the sinus and as
endoscopic surgery, especially with the computer-assisted techniques, has
improved the ability to improve sinus function, physicians are returning
to sinus treatment as an aid to asthma management. Further aids to
treatment have included newer antibiotics and emphasis on cilia function.
Newer medications, such as the corticosteroids sprays, have given new
directions for treatment. Indeed, many allergists now emphasize their role
in treating sinusitis.
Pathophysiology:
The physiology of mucus in
individuals with asthma is similar to that of nasal mucus. Mucociliary
clearance (MCC) involves cilia and the layers of mucus on the ciliated
epithelium and refers to the movement of particles along a desired path
for maximum health. In the upper respiratory tract, cilia propel the mucus
and its trapped bacteria and particles to the nasopharynx, where it drops
to the hypopharynx and is swallowed. The stomach acid then disposes of the
unwanted invaders.
In the lower respiratory tract, the cilia that line the trachea and
bronchial tree similarly move the mucus blanket up the trachea and into
the hypopharynx for swallowing.
The science of rheology investigates the makeup of this liquid and
studies its viscosity and elasticity. Two layers of mucus are present over
the ciliated cell; an outer thick, viscoelastic, semisolid mucus layer,
which the cilia do not strike directly, is found over a layer of watery
serous fluid. Because of the lowered viscosity of the layer of watery
serous fluid, the cilia are able to beat normally and to move the watery
lower layer, thereby affecting movement of the upper thick layer. Changes
of these properties affect movement of the mucus blanket and play a major
role in pulmonary and sinus disease. If the movement of the blanket is
slowed, bacteria are able to multiply as the mucus thickens and stagnates.
Nasal mucus is a secretory substance produced by 100,000 small
seromucous glands in nasal mucosa. Nasal mucus has a lower viscosity than
sputum and contains sulfate, sugars, proteins (including albumin), and
protective enzymes and phagocytes.
MCC refers to the function of moving bacteria, contaminants, and
carcinogens away. Ciliary beat frequency refers to the number of full
whiplike movements of the cilia per second (normally 16) and involves the
coordination of these movements.
Remarkably, the ciliary movement is coordinated so that an effective
wave propels the mucus in a specific direction. Sinus cilia beat toward
the natural sinus opening in the middle meatus, even after an antrostomy
or artificial opening is created in the inferior meatus. Nasal cilia beat
backward towards the nasopharynx. Thus, nasal mucus is propelled into the
nasopharynx and is swallowed for disposal into the stomach. In the child,
this course directs the mucus with its bacteria, debris, and foreign
matter over the adenoids where lymphocytic defenses can act. The deep
crypts and rugae of the adenoids create a larger surface area for greater
effect.
Protection from infection is achieved by the presence of lysozymes,
immunoglobulins, and phagocytes in the mucus solution. Movement of the
bacteria by mucus flow reduces opportunity for penetration of the cell.
Dilution of bacterial products makes them less toxic. Anything that thins
the nasal mucus or stimulates it (eg, proteolytic enzymes, mucolytics)
helps the asthmatic chest mucus. Measuring cilia in the chest is quite
difficult; measurement requires biopsy or special radioactive gasses.
Measuring the nasal cilia, as by a saccharin test, is easy and is a useful
reflection of the chest cilia.
Frequency:
- In the US: Asthma and sinusitis are both increasing
in frequency. Fifteen million individuals with asthma and 35 million
persons with sinusitis live in the United States. No doubt, overlapping
of the conditions occurs.
- Internationally:
An increased incidence is reported
in all countries. The incidence of sinusitis is higher in Japan,
Indonesia, and Europe than in the United States. An increasing incidence
of both sinusitis and asthma occurring together is reported
internationally as well as in the United States. Certain areas have
special conditions causing an increased sinusitis incidence (eg, the
fires of Kuwait and Indonesia, the chromium content of the sands of
Saudi Arabia). Asthma-free areas have been noted in certain sub-Saharan
areas where hookworm is endemic. The parasite system (eg, eosinophiles)
is fully engaged.
Mortality/Morbidity:
Despite the availability of
effective antiasthmatic drugs, asthma is responsible for more than 100
million days of restricted activity and 470,000 hospitalizations annually.
The most common disease of early childhood, asthma exacts a particularly
high toll among persons who are economically disadvantaged.
- In poverty situations, the incidence of asthma and allergy is
higher. This increased incidence is partially based on poor
environmental control. Cockroaches and dust are known to be causes of
asthma. In situations of poverty, pets are often prevalent in close
quarters, and air filtering and dust proofing often are not performed.
Asthma is a disease that requires maximum cooperation of the family.
Often, the parents must oversee a complicated regimen of inhalers,
pills, and breathing exercises; this type of supervision and assistance
may not be available in poverty situations. Poor medical service also is
a major factor contributing to the high rate of poorly controlled asthma
and sinusitis in these patients. Often, the only primary and follow-up
care for this population of patients is in the busy emergency
department.
- Sinusitis, fortunately, has a low death rate. Death can occur in
young children when the condition is unrecognized. In infants, the
maxillary sinuses are well developed but are often unrecognized as a
source of possible lethal infection. In adults, fatalities occur
primarily as a result of complications of sinus infection to the brain,
meninges, and the cavernous sinus.
- Problems with sinusitis and rhinitis can make up 50% of office
visits and are involved in a large percentage of medical costs.
Sex: Incidence of sinusitis appears to be equal
between the sexes.
Age: Asthma and sinusitis can occur in very young
children. Sinusitis in very young children is not appreciated because the
presence of the maxillary and ethmoid sinuses is not always recognized.
Once children start nursery school, the incidence of sinus and chest
infections increases dramatically.
History: Individuals with
asthma often have a childhood history of allergy. Patients present with
wheezing and coughing, and they report sleepless nights. These patients
benefit from the use of an inhaler. Associated with these symptoms are
symptoms of frequent sinus infections, heavy pus, or thick mucus drainage
into the chest. Whenever individuals with asthma get a sinus infection,
the asthma worsens. When accompanied by a sinus infection, the asthma does
not clear with simple treatment. When the nose obstructs, these
individuals breathe with the mouth open, which precipitates an asthma
attack. Patients with asthma have a dry mouth all the time and are
bothered by thick nasal phlegm dripping into the throat. The thick phlegm
causes these patients to cough and try to clear the throat constantly.
With a sinus infection, a much longer time period is required to clear the
asthma. Obtain history regarding frequency of bouts of nasal obstruction,
purulent discharge, localized sinus pain, drainage, and fever.
- Determine the frequency of symptoms.
- History of frequent bouts of sinusitis is evidenced.
- Every year, 4-5 episodes of sinusitis occur and last about 4 weeks
each.
- Often, the episodes do not clear until antibiotics are
administered.
- A history of nonchronic sinusitis is as follows:
- A history of 4 bouts of sinusitis over the past 6 months, each of
which required antibiotics and did clear, is more suggestive of a
single infection hanging on.
- When the antibiotic is stopped, the infection, still present,
gradually returns.
- In this case, irrigation is needed as well as possible local
treatment or a longer course of antibiotic.
- Family history includes the following:
- Obtaining family history is very important in cases of asthma and
allergies.
- For sinusitis, a higher incidence generally does not follow a
family history of sinusitis.
- The following 2 factors cause a very high incidence of sinusitis in
patients with AIDS:
- Lowered immune systems allow bacterial growth.
- A thickened mucus exudate becomes stagnant and allows for
bacterial growth.
- The failure of the normal mucociliary flow system accounts for an
extremely high incidence of sinus disease in patients with cystic
fibrosis.
Physical: In susceptible individuals, this
inflammation causes recurrent episodes of wheezing, breathlessness, chest
tightness, and coughing, particularly at night or in the early morning.
These episodes are usually associated with widespread, but variable,
airflow obstruction that is often reversible either spontaneously or with
treatment. The inflammation also causes an associated increase in the
existing bronchial hyperresponsiveness to a variety of stimuli.
- Determine whether sinus infection precedes or follows asthma attack.
- Determine the frequency of sinusitis and results of antibiotic
therapy.
- Examine the eyes, ears, nose, throat, and larynx. Look for lymphoid
hyperplasia and/or hypertrophic turbinates. Determine if they are
inflammatory or allergic in appearance.
- Determine if the septum is obstructive. On laryngoscopy, look for
signs of irritation of the posterior larynx indicating gastroesophageal
reflux disease (GERD).
- Look for history of eustachian tube dysfunction.
- Look for signs of adenoid hypertrophy or mass.
- Hypertrophic posterior turbinates may best be observed via
nasopharyngeal mirror examination.
- In cases of unilateral purulent drainage from a child, especially
look for a foreign body.
- Perform nasal endoscopy to reveal patent or closed sinus ostia (see
Image 1).
- Visualize the maxillary, frontal, and sphenoid ostia.
- Physical findings of asthma include the following:
- Individuals with asthma wheeze and have impaired breathing.
- The chest is sometimes retracted or sunken, indicating inhalation
difficulty. (Barrel chest indicates emphysema.)
- Physical findings of sinusitis include the following:
- Patient breathes through the mouth and shows purulent drainage.
- Patient may have a mild fever.
- Local tenderness over the affected sinus is present.
- With nasal speculum, a purulent drainage is usually observed from
the middle meatus.
- Transillumination shows decreased light passage on the affected
side.
- Purulent material may be observed in the pharynx and/or the
nasopharynx.
Causes: Asthma and sinusitis are increasing in
frequency and morbidity, despite the advances made in understanding and
treating these conditions. The following theories suggest what is causing
these increases:
- A current theory suggests that with overuse of antibiotics, the
normal disease reaction is replaced by a hypersensitivity reaction.
- This theory notes a high incidence of disease in families with
upper incomes; these individuals have full access to medical care,
cleanliness, and dust proofing.
- The body's immune system is designed to fight parasites and
infections, and if the antibiotic is administered at the first sign of
illness, perhaps the normal immunity does not develop and alternate
systems are produced (eg, asthma, poor resistance to infection).
- When compared to sinusitis, asthma has more of a genetic etiology.
- Incidence of asthma increases when both parents have asthma.
- More individuals with asthma are having children.
- Environmental factors: These factors are becoming increasingly more
important and include the following:
- The major environmental irritant, other than specific occupational
substances, is tobacco smoke.
- Current theory attributes the increase of sinusitis and asthma to
air pollution. When the air is polluted with smog, diesel, gasoline,
and other noxious products, the sun's heat and rays may combine them
into dozens of products whose long-term effects are unknown at this
time.
- Additionally, smog, diesel fumes, and sulfur dioxide all combine
to interfere with good cilia function. Hypersensitivity reactions seem
to occur when the individual has an overwhelming exposure and does not
recover ciliary function. Unfortunately, new solvents are marketed
daily and the effect on cilia function is not provided by the
manufacturers. Even more unfortunate is the fact that despite the 50
million dollars spent by the Federal Drug Administration (FDA) on
clinical evaluations, no drugs are evaluated as to their effect on
mucociliary clearance.
- Known industrial toxins include chlorine, sulfur dioxide, cupric
compounds, and chromium dusts.
- Fires are a known factor. When countrywide fires occur, such as in
Kuwait or Indonesia, the incidence of sinusitis and asthma increases.
Oil fires in Kuwait released polymelia aromatic hydrocarbons, nickel,
and vanadium into the atmosphere. This contamination resulted in upper
and lower respiratory infections. Similar problems have occurred with
Indonesia forest fires and excess smog experienced in London. Some of
the respiratory problems might be prevented by simple irrigation with
Locke-Ringer–type solutions.
- Other environmental problems to be considered include pet
allergens, house dust mite allergen, cockroach allergen (most
significant in patients who live in the inner city), indoor fungi and
molds, and outdoor allergens (eg, trees, grass, weed pollens, seasonal
mold spores).
- Impaired mucociliary clearance: Sinusitis and asthma are
inflammatory diseases and, as such, are caused or aggravated when
mucociliary clearance is impaired. Factors that slow cilia include the
following:
- Cocaine
- Antihistamines
- Dehydration
- Inhalation of air or steam hotter than 40 degrees Celsius
- Heavy load of iced drinks
- Chilling drafts
- Sulfur dioxide, ozone, smog
- Inhalation of chromium dusts
- Cupric (copper) compounds
- Nickel dusts
- Chimney dusts
- Formaldehyde
- Late stages of allergy
- Nasal polyps
- Skydrol (a solvent used in airplane maintenance)
- Infections with Pseudomonas species, Haemophilus
influenzae, and many viral pathogens
- Hyperbaric oxygen
- Reduction of airway diameter
- AIDS
- GERD: In addition to the above factors, recognition of GERD as an
irritant that brings on asthmatic symptoms, as well as throat and
laryngeal symptoms, is increasing. When the larynx is visualized with
mirror or endoscope, the arytenoids are inflamed, especially
posteriorly. Standard GERD measures may be beneficial.
- Bacteria: Dye or tracers placed in the sinus appear 16 hours later
in the lower trachea. Thus, little question exists that bacteria from
the sinuses find their way to the lower respiratory system. Bacteria
then act as an inflammatory agent.
Foreign Bodies of the Airway
Other Problems to be Considered:
Differential diagnosis of asthma includes the following:
Chronic
obstructive pulmonary disease (chronic bronchitis or
emphysema) Congestive heart failure Cough secondary to drugs (eg,
angiotensin-converting enzyme inhibitors) Laryngeal dysfunction (eg,
ventricular dysphonia) Mechanical obstruction of the airways (eg,
tumors, anatomic changes) Retrosternal thyroid Pulmonary
embolism Pulmonary infiltration with
eosinophilia Bronchostenosis Enlarged lymph nodes Foreign body in
trachea or bronchus Laryngeal webs Laryngotracheomalacia (primarily
in infants) Tracheal stenosis in infants Tumor Vascular
rings Vocal cord dysfunction Bronchopulmonary dysplasia Cystic
fibrosis Heart disease Obliterative bronchiolitis Viral
bronchiolitis Aspiration from swallowing mechanism
dysfunction GERD Recurrent cough not due to asthma Environmental
irritants
Differential diagnosis of sinusitis includes the
following:
Cervical or temporal mandibular joint (TMJ) referred
pain Allergic rhinitis Nasal polyps Foreign body (common in
children; characterized by unilateral purulent odorous drainage) Acute
common cold Deviated nasal septum Rhinitis medicamentosum
|
Lab Studies:
- Culture purulent discharge.
- Unfortunately, culture taken directly from the nose may not yield
correct information. Most healthy persons harbor potentially harmful
bacteria.
- The best culture is taken directly from the sinus cavity by
insertion of a sterile needle and aspiration into a sterile container.
- Sensitivity studies are usually needed and are of value when the
specimen has been taken by puncture aspiration.
- In individuals who are diabetic and/or immunocompromised, the
culture program includes culture for fungus.
- If the patient has had many antibiotics and has chronic sinusitis,
a fungus growth may show up on fungus culture. However, this may not
be the cause of the sinusitis.
- Generally, bacterial exudates are in the nasal chambers. Cultures
show H influenzae, Neisseria catarrhalis, and Haemophilus
pneumoniae. Cultures may also show streptococci infections
- White blood cell count and differential count is as follows:
- As in any infection, WBC differential count helps differentiate
between viral and bacterial infection.
- Test for infectious mononucleosis when adenopathy and tonsillitis
accompany the sinus infection.
- In cases of chronic sinusitis, some authors test the skin for fungus
and then desensitize it for strong positive reactors.
- Biopsy of the nasal membrane may be used to obtain tissue to be
measured for cilia activity. This is often a research procedure.
- The saccharine test of nasomucociliary flow is indicated if a
history of toxic exposure exists or if cystic fibrosis is suggested.
This test can be used to gauge the degree of reduced cilia activity.
- In most cases of chronic sinusitis, the saccharin test of
mucociliary flow shows impaired cilia action. This usually reflects
the cilia of the chest.
- Place a particle of saccharin one-fourth inch behind the anterior
edge of the turbinate. Instruct the patient to sit quietly to not
sniff or sneeze. Ask the patient to swallow every 30 seconds and
report when the sweet saccharin is tasted. The patient's report
measures the speed of the nasal cilia as they propel the particle to
the nasopharynx. The following measures are related to cilia activity:
- In acute allergy, the saccharin is tasted in 5 minutes or less.
- With normal nasal conditions, the saccharin is tasted in 5-8
minutes.
- With infection and late stage allergy, the saccharin is tasted
in 9-19 minutes.
- With atrophic rhinitis and chronic sinusitis, the saccharin is
tasted in 20-29 minutes.
- After exposure to chlorine gas or other toxins, saccharin is
tasted in more than 30 minutes. These patients do not recover their
cilia function with treatment.
Imaging Studies:
- Radiography of the sinuses is quite helpful and generally includes
Waters, lateral, and Caldwell views.
- To perform the Waters view, place the patient's chin on the
radiograph plate and the nose 1-1.5 cm above the plate. This
positioning provides the best view of the maxillary sinus with the
petrous ridge being below the inferior portion of the maxillary sinus.
- The lateral view ideally shows the frontal and sphenoidal sinuses
as well as the ethmoid sinuses in lateral projection. However, these
views have been replaced with CT scan views that often provide
exquisite detail of the sinus anatomy.
- The Caldwell view, in which the nose and forehead are on the
radiograph plate, is designed to visualize the frontal and ethmoidal
sinuses.
- CT scanning involves the following:
- CT scanning has replaced regular radiography as the preferred
imaging test to look at the sinuses.
- In most communities, the radiologist obtains a limited CT scan for
about the price of a regular sinus radiograph.
- In cases of sinusitis, localizing the condition by means of CT
scanning and correcting anatomic factors is important.
- The limited CT scan shows the maxillary ostia. Look for pathology
of the nasoantral opening of the maxillary sinus. If this opening is
compromised, then referral to the otolaryngologist is indicated.
- With a CT scan, the bony anatomy, including the important
structures of the maxillary frontal and sphenoid ostia, is detailed.
The cribriform plate, whose anatomic position is a critical factor in
any surgery, is visualized. The surgeon looks for depression at this
area and dehiscence.
- In chronic sinusitis, a CT scan of the sinuses is often needed to
pinpoint foci of infection and patency of ostia.
- Primarily look for conditions that may impair drainage, especially
from the maxillary ostia. These conditions may be nasal polyps,
thickened mucosa, enlarged turbinates, concha bullosa, or even a
deviated septum (see Image 2). The diseased sinuses can be clearly
identified. If the ostia are patent, the patient should respond to
systemic management. If the sinus openings are fully closed, then
systemic therapy may be insufficient, and surgical correction may be
required.
- MRI involves the following:
- MRI of the sinuses produces excessive false-positive results
because the MRI is too sensitive. Commonly, patients who have had an
MRI for unrelated causes are referred to the ear, nose, and throat
(ENT) office with a diagnosis of sinusitis from the MRI results but
with a negative history of purulent drainage, nasal congestion, or
fever. This is because any liquid can show up as disease on an MRI. If
the patient is reported as having sinusitis based on the MRI only,
this finding can be ignored.
- MRI is of use in diagnosing fungal infection. Usually a sinus
filled with fungus has a characteristic appearance.
Other Tests:
- Allergy tests may be indicated and can be performed in the office by
intradermal testing, ie, prick testing or radioallergosorbent assay test
(RAST). RAST and other laboratory tests are performed from blood removed
from the patient. Results are usually accurate, and a treatment serum
can be made based on these results. Persons can have anaphylactic
reactions to these tests, and the means of treatment must be immediately
available.
- Food allergies are difficult to test for. A careful history provides
the best identification of a food allergy. Once the food is identified,
adding the food to the test to induce a reaction is best in order to
prove the allergy. Then, prescribe an allergy-free diet with avoidance
of test-identified foods.
- Lyme disease, HIV, infectious mononucleosis, leukemia, and other
diseases can all mimic sinus and chest conditions and must be assayed
for difficult cases.
- Cystic fibrosis must be considered in the patient with recurrent
sinus and chest infection. The sweat test indicates this diagnosis, as
does the saccharin test of cilia function.
- Pulmonary function studies indicate respiratory function.
- Daily expiratory flow measurements are necessary in asthma.
- Take the time to be assured that the patient/parents fully
understand how these measurements are performed and how to perform the
important daily log-keeping of the maximum expiratory flow rate.
Demand that the patient bring the meter to the office from time to
time to check on technique.
- The more expensive flow-rate meter is not necessarily the best
model; however, some doctors are recommending the new computerized
models that store rate values and are not dependent on the patient's
record-keeping skills.
Procedures:
- Laryngoscopy: Look for signs of irritation of the posterior larynx
indicating GERD.
- Nasopharyngeal mirror examination: Hypertrophic posterior turbinates
may be observed. In cases of unilateral purulent drainage in a child,
especially look for a foreign body.
- Nasal endoscopy: Patent or closed sinus ostia may be revealed. The
maxillary, frontal, and sphenoid ostia are visualized. Purulent
discharge is noted (see Image 3).
Histologic Findings:
Biopsy may show absence of cilia or squamous changes of nasal
cilia. The best diagnosis of cilia dysfunction is obtained when the biopsy
tissue is placed into solution and the cilia frequency is measured by
strobe or similar means. The strobe frequency is adjusted to match the
cilia frequency.
Medical Care: Whether
sinusitis and asthma are caused by inflammation or allergies has been
questioned. Today, sinusitis and asthma are attributed to inflammatory
effect. An excellent example of this is the existence of nasal polyps.
With administration of corticosteroids (both oral and topical), polyps may
not shrink; however, if an antibiotic is added at the same time as the
corticosteroids, clearing of the polyps from the nasal cavity with
clearing of the blockage occurs in more than 90% of the author's patients.
Patients prefer this form of treatment to surgery.
Treatment consists of using measures to increase mucociliary clearance.
To help cilia movement in the chest and nose, a deep-throated
"oooooommmmm" vibration is useful to help break up thick mucus. Patients
should drink enough fluids (eg, hot tea, hot chicken soup) to lighten the
urine. Bacterial load should also be reduced. This may be achieved by
terbutaline, inhaled corticosteroids, various enzymes (eg, Bromelin or
Papain taken buccally), pseudoephedrine, breathing and coughing exercises,
flutter inhalation device, iodides, guaifenesin, irrigation, Locke-Ringer
moisturizer spray, and exercise.
Many cases of sinusitis do not respond to treatment because (1) the
wrong antibiotic is prescribed; (2) duration of the antibiotic is too
short (treatment may require 6 wk); (3) drainage, rest, and
anti-inflammatories are not combined with treatment; (4) fungus is
present; and (5) the mucociliary system fails. If infection does not clear
in 6 weeks, referral to ENT is recommended.
Because bacteria and thick phlegm play a significant role, the
physician can reduce the asthmatic symptoms from sinusitis by suctioning
or irrigating in the office if pus is present in the nose or sinuses. One
technique is to use a vasoconstrictor in the nose, wait 2 minutes, and
then irrigate with a modified Locke-Ringer solution or sodium chloride
solution with pulsatile nasal/sinus irrigator, such as the Hydro Pulse.
Not only is a considerable amount of surface and sinus pus removed, but
also the pulsatile action at 20 pulses per second stimulates the cilia of
the nose and sinuses to restore normal cilia action (see Image 4). This
same procedure can be used daily at home for chronic sinusitis in adults
and children aged 5 years and older (Rachelevsky, 1989).
Pulsatile irrigation may also be beneficial to the patient with
allergies during the pollen season. Daily irrigation reduces the pollen
load in the nose and the immunoglobulin E (IgE) levels in the nose and in
the circulation (Subiza, 1999).
If asthma and sinusitis are considered as being inflammatory diseases,
treatment is clearly similar for both in regards to specific infection,
inflammation, drainage, attention to thinning mucus, and restoring cilia
and comfort to the patient.
- Antibiotics
- Most common organisms are Streptococcus pneumoniae, H
influenzae, and Moraxella catarrhalis. Increasingly
resistant strains of bacteria are developing. Standard treatment for
acute sinusitis must include antibiotics for H influenzae and
S pneumoniae. Treatment is usually one of the following:
- Amoxicillin 500 mg 3 times a day
- Trimethoprim-sulfamethoxazole (Septra DS) twice daily
- Cefuroxime (Ceftin) 250 mg twice daily
- Cefaclor (Ceclor) 500 mg 3 times a day
- Other medications include the following:
- Trimethoprim-sulfamethoxazole double strength (Bactrim DS) twice
daily
- Cefixime (Suprax) 400 mg once daily
- Loracarbef 400 mg twice daily
- Augmentin 400 mg 3 times a day
- Clarithromycin (Biaxin) 500 mg 2 times a day
- Azithromycin (Z-Pak) 250-mg tablets, 2 the first day followed by
1 every day for 4 more days
- Erythromycin adult dose for chronic sinusitis
- For chronic sinusitis, usual pathogens, anaerobes, and
Staphylococcus aureus are involved. Start amoxicillin 500 mg
3 times a day, amoxicillin with clavulanate (Augmentin) 500 mg 3 times
a day, or clindamycin (Cleocin) 150-300 mg every 6 hours. With all
antibiotics, patients should take a full glass of water before and
after each dose. Antibiotic sensitivities change almost daily and from
region to region. Physicians must receive and use the drug
resistance/sensitivity data available from hospitals.
- For treatment of Pseudomonas infections, use
piperacillin, ticarcillin, and carbenicillin, depending on the
secondary organisms.
- Anti-inflammatory agents: Sinus pain is present when membranes are
inflamed or swollen. Anti-inflammatory agents (eg, Naproxen) are useful.
- Steroids: One of the major advances in sinus and asthma treatment
has been in the use of steroids. These are anti-inflammatory and serve
well to reduce these factors.
- Oral steroids: Prednisone is useful for allergic rhino sinusitis
and may be administered as prednisone 5 mg number 21. It is prescribed
in diminishing doses, as follows: 6 tablets the first day, 5 tablets
the next day, and so on to 1 tablet the sixth day. These should all be
taken at one time and not spaced out. Medrol Dosepak is used
similarly. Systemic corticosteroids include Decadron for quick action
and Celestone for delayed action. These are excellent for
anti-inflammatory purposes.
- Steroid sprays: These are very common today. Commonly used are
beclomethasone dipropionate (Beconase AQ), triamcinolone acetonide
(Nasacort AQ), and fluticasone propionate (Flonase). Budesonide
(Rhinocort Aqua) has the advantage of being without benzalkonium.
Compared with the oral antihistamines, the sprays have the advantage
of effectiveness and few adverse effects. Adverse effects of steroid
sprays include atrophic changes and epistaxis. After 3 months of daily
use, check to see if thinning of the membranes, crusting, or bleeding
is present. If these are present, stop the steroid spray use. A course
of saline spray without benzalkonium, a moisturizer ointment can
reverse this adverse effect. Rhinocort Aqua does not contain
benzalkonium and may have fewer adverse effects.
- Mucolytic medications: Whenever stasis occurs, mucus thickens and
bacteria multiply. Thinning the mucus is important in order to restore
mucociliary clearance. Drinking hot tea with lemon and honey is one of
the best treatments, as is ingesting chicken soup. Most cold drinks slow
cilia.
- Guaifenesin: This is a common mucolytic present in Robitussin and
other cough preparations. Some authors dispute its value. The dose
needed is 1200 mg twice daily. Preparations combined with
decongestants (eg, Entex LA, Zephrex LA, Aqua Tabs) are popular and
clinically appear to be beneficial.
- Proteolytic enzymes: These enzymes (eg, papain, bromelain) reduce
certain aspects of inflammation and thin mucus. Few known adverse
effects are associated with these enzymes, especially if taken via the
buccal route. The buccal route is the preferred route because enzymes
are inactivated by stomach acid and, even when taken on an empty
stomach, maximum absorption is less than 40%. One buccal tablet is
Clear Ease, which contains one million enzyme units of bromelain (from
pineapple) and one half million enzyme units of papain (from papaya).
- Iodides: Potassium iodide is a useful mucolytic medication.
- Saline sprays: These can help keep the nose moist and thin the
mucus. Using preparations without benzalkonium or thimerosal is
important. Some of the spray bottles can be used for mist or for
stream, which is useful when removing heavy dust or perfume from the
nose is necessary. In 1999, Boek recommended Locke-Ringer solution as
being superior to regular isotonic sodium chloride solution.
Hypertonic sodium chloride solution may be of advantage in swollen
turbinates, but patients have difficulty in using this.
- Decongestants: Pseudoephedrine (Sudafed) has long been a favorite to
open a stuffy nose. It is contraindicated in hypertension and in persons
who are kept awake by the drug. Strangely, this drug may make children
younger than 12 years drowsy. Spray decongestants include the following:
- The effects of oxymetazoline last longer than the effects of
neo-synephrine. Privine may cause drowsiness. For many years, Afrin
was thought to cause rhinitis medicamentosum by shrinking the nose and
then having rebound swelling. Today, the rebound addiction is thought
to be caused by the benzalkonium; oxymetazoline is available without
benzalkonium. One product is Natru Vent nasal decongestant.
- Ipratropium bromide (Atrovent) is an acetylcholine blocker
generally used as a bronchial dilator in the lungs but now used as a
nasal spray.
- Azelastine HCl (Astelin) is an antihistamine in spray form. This
drug is excellent when steroid sprays are contraindicated. Many
patients dislike the taste. A solution of Benadryl 25 mg added to one
ounce of Locke-Ringer or sodium chloride solution can be made and
yields similar results. The dose of the Benadryl must be titrated to
the individual patient.
- Cromolyn (Nasalcrom) nasal spray is highly effective for allergies
if started 6 weeks before the pollen count gets high. Pollen calendars
are available on the Internet (eg, AllergyBuyersClub.com)
- Topical medications
- Various moisturizing ointments are available to moisturize the
nose, including AYR gel.
- Topical antibiotics are useful in the nose and sinus. Neosporin
ointment may be used for mild local infection. Bactroban ointment has
been used extensively as a topical antibiotic with no reported adverse
effects. This ointment can be added to Locke-Ringer or sodium chloride
solution as a spray.
- Gentamicin and tobramycin are used for irrigation (Davidson,
1995). Gentamicin has the advantage of being inexpensive; 40 mg can be
added to 200 mL of Locke-Ringer or sodium chloride solution for
irrigation with a pulsatile irrigation device. This can be used twice
daily for advanced infection or once daily for milder chronic cases.
Singulair taken orally or dissolved in Locke-Ringer or sodium chloride
solution has been reported to be of particular value in vasomotor
rhinitis.
- Example of local irrigation is as follows: For topical irrigation
with gentamicin or tobramycin, add 1 teaspoon of Breathe Ease or salt
to 1 pint of water in irrigator basin. Irrigate until clear. Blow nose
gently until clear. Adjust solution to contain 200 mL of solution and
add 40 mg of gentamicin or tobramycin. Irrigate with full amount. Do
not blow the nose. Use twice daily in the heavy purulent stage and
then once daily during the clearing stage. Average treatment duration
is 3 weeks.
- Organisms and generally used antibiotics
- Pneumococcus infections: Use penicillins, amoxicillin,
erythromycin, and cephalosporins.
- H influenzae: Use amoxicillin or amoxicillin with
potassium clavulanate (Augmentin); macrolides such as erythromycin
plus sulfasoxazole (Pediazole); cefuroxime (Ceftin); and trimethoprim
and sulfamethoxazole (Septra, Bactrim).
- Staphylococcal infections: Use amoxicillin plus potassium
clavulanate (Augmentin), erythromycin, and dicloxacillin.
- Pseudomonas infections: Use aminoglycosides,
ciprofloxacin, and ofloxacin.
- General classification of antibiotics
- Antimicrobials such as penicillin G and V are bacteriocidal
because they inhibit cell wall synthesis.
- Antistaphylococcic penicillins include dicloxacillin (Dynapen).
- Amino-penicillins include ampicillin and amoxicillin.
- Augmented penicillins include amoxicillin plus potassium
clavulanate (Augmentin).
- Antipseudomonal penicillins include ticarcillin and carbenicillin,
which are for IV use.
- Cephalosporins are bacteriocidal (they inhibit cell wall
synthesis). First-generation cephalosporins include cefazolin and
Ancef for IV administration and cephalexin, cefadroxil, Duricef, and
Keflex. Second-generation cephalosporins include cefuroxime (Ceftin)
and cefaclor (Ceclor). Second-generation equivalents include
loracarbef (Lorabid). Third-generation cephalosporins include cefixime
(Suprax).
- Macrolides include erythromycins, clarithromycin, and
azithromycin.
- Clindamycins include Cleocin and Lincocin.
- Tetracyclines inhibit protein synthesis. Bacteriostatic
tetracyclines include minocycline and Vibramycin.
- Aminoglycosides can be ototoxic, are bacteriostatic, and inhibit
synthesis. They include streptomycin, neomycin, gentamicin,
tobramycin, and amikacin.
- Quinolones include ciprofloxacin (Cipro) and ofloxacin (Floxin).
- Sulfonamides are bacteriostatic but, when used with other
antibiotics, are synergistic.
- Trimethoprim and sulfamethoxazole include Septra and Bactrim.
- Antifungal medications include amphotericin B, ketoconazole, and
fluconazole (Diflucan).
- Antiviral medications include acyclovir (Zovirax) and amantadine
(Symmetrel).
- Irrigation/aspiration: Clearing sinus infection is indicated for the
individual with asthma. Irrigation/aspiration at the first office visit
is a useful step in order to reduce the bacterial load. When the sinus
infection does not clear with antibiotics, prescribe daily irrigation,
mucolytics, and anti-inflammatory medications. Follow with a CT scan of
the sinuses.
- Sinusitis and asthma occur in younger children (see Image 5). One
useful technique for treating sinusitis in children is Proetz sinus
irrigation, which is performed by placing the child hyperextended over
the parent's lap so that the child's head is lowered. Ideally, the
child's chin and ear are in a straight line perpendicular to the
floor. The child's vasoconstrictor (eg, 1/8% Neo-Synephrine) is placed
in both nostrils. Fill both sides with modified Locke-Ringer solution
(Breathe Ease) or sodium chloride solution. Take care not to get into
the eyes. Gently aspirate with a nasal aspirator. Keep refilling both
sides with solution until the return is clear. This works better if
the child cries. By removing this pus, the chance of developing a
chronic sinus condition with an asthmatic sequel is diminished.
- Nasal moisturizer spray is also of benefit to young children.
Breathe Ease is specially designed to be used by small hands and
contains a modified Locke-Ringer solution without benzalkonium. This
does not sting or burn and is used by most children as a nasal spray.
(The spray can be made more attractive to children, for example, by
placing a sticker of the child's hero on the spray bottle.) Or
isotonic sodium chloride solution can be prepared without
preservatives. One half teaspoon of salt to 8 ounces of water makes an
isotonic solution. Because no preservatives are added, the solution
should be changed weekly.
- Caution: When daily use of nasal spray for children occurs, pay
particular attention to preservatives such as Thimerosal. The Academy
of Pediatrics has recommended against its use, but it is still
contained in certain nose drops. If the product is used long term,
consider checking for mercury levels. Benzalkonium, another
preservative, burns and stings and discourages the child from using
the spray.
Surgical Care: Sinusitis may require surgical care.
Primarily, the disease is a matter of obstruction of sinus drainage. If
sterile cotton is placed in the healthy nose, whichever sinus is blocked
becomes purulent. This is because the blockage prevents drainage along the
mucociliary pathways, macrophages do not have access to the area, and
bacteria are free to multiply. Surgery is directed at making sinus
drainage adequate and effective.
The advances in FESS surgery make it easier and safer to clear the
source of sinus disease. Insta-Trak delivers a 3-dimensional picture to
the operator of the position of the instrument while the operator is
performing surgery. This increases surgical success and reduces risk. A
full CT scan of the sinuses is taken preoperatively. Metal markers are
fixed on the patient and kept for surgery. At surgery, the same markers
are placed in the designated areas. A magnet is placed on the suction. A
screen shows the sinuses in 3 views. The device is used to visualize the
position of the magnet in the 3 views at all times, thereby reducing the
complication rate (see InstaTrak Image-Guided Surgery ).
- Maxillary sinus
- Blockage of the natural ostia can be caused by a foreign body. A
deviated septum may compress this area. Hypertrophy of turbinates may
be sufficient to block the opening. Concha bullosa refers to a hollow
enlargement of the middle turbinate so that it blocks drainage of the
maxillary ostia (see Image 6). More commonly, mucosal hypertrophy
blocks the ostia. Over time, the maxillary sinus shows a worsening of
the disease process. An aberrant air cell of the ethmoid may obstruct
the maxillary sinus opening. Nasal polyps may develop in the opening
itself or grow from a distal origin and be positioned to obstruct the
ostia (see Image 7).
- Treatment is directed to ensure sinus patency and to remove
obstructive septum, polyps, and tissue. At surgery, obstruction to
drainage is removed and instruments can enter the sinus cavity to
remove diseased tissue. When patients report pain in the cheek and
upper teeth, remember that the same nerve innervates the maxillary
antrum and the upper teeth and that differentiation of the source of
the pain is between dental and sinus origin.
- Ethmoid sinuses
- Ethmoid sinuses open into the middle meatus and the superior
meatus. The same factors as above are involved (ie, polyps, turbinate
hypertrophy, mucosal hypertrophy, septal deviation).
- With the ethmoid sinuses, removing all diseased tissue, as well as
obstructive conditions, is important. The ethmoid sinuses may cause
infection into the globe of the eye. If the eye is swollen, consider
obstruction of the ethmoid sinuses. Patients show puffy eyes, black
eyes, and obstruction to breathing.
- Sphenoid sinuses: Symptoms with the sphenoid sinuses are more
diffuse and may manifest only as a headache and continued fever.
Endoscopic examination shows obstruction to the opening of the sphenoid
sinus, which must be cleared. CT scans are vital to evaluate the mucosa
and the position of the sinus itself in relation to the brain and optic
system. Normally, the right and left sphenoids are highly variable, and
missing the wall of the opposite sinus as it deviates far to the
opposite side is an easy error to make. In a patient with vague pain,
elevated white count, and no signs of sinusitis on examination,
endoscopic evaluation and CT scan may be the only means of diagnosing
sphenoid sinusitis.
- Frontal sinus
- In addition to the usual causes of sinus obstruction, another
factor adds to mucosal thickening, polyps, and anatomic obstruction.
Following FESS surgery, during which the attachment to the lateral
nasal wall may be compromised by removal of turbinate attachment at
the sinus ostia, the middle turbinate may dislodge, swing forward, and
obstruct frontal drainage.
- Surgery consists of opening drainage channels. The frontal sinus
drainage channel is somewhat long and obstruction can easily occur.
Importantly, watch for severe pain or change in pain in the frontal
area. An abscess may weaken or open the posterior wall into the skull
cavity with serious effect. In such cases, immediate surgical
correction is needed. Palpation of the floor of the frontal sinus may
be diagnostic.
- Chronic frontal area pain: Often, patients report pain in the
frontal sinus area without fever or purulent nasal discharge for weeks
or months. This pain usually is of cervical origin, characterized by
painful cervical muscle areas posteriorly that refer pain to the frontal
area (course of V1). Palpating the cervical area is helpful; look for
trigger points and areas of referral to the frontal area. Less commonly,
the pain can refer to the maxillary area (V2).
- Removal of excess mucosa
- A serious complication occurs following nasal and/or sinus surgery
when excess mucosa is removed as in complete turbinectomy. Here, the
nose may appear wide open yet the patient reports pain on breathing,
burning, and not getting enough air.
- Once large amounts of turbinate tissue have been removed, atrophic
rhinitis with crusting takes place and requires frequent moisturizing.
These patients are highly symptomatic because of the absence of normal
nasal tissue that moisturizes and filters. Some of these patients have
disabled nasal function because of the dryness, crusting, and
discomfort. This has a serious effect on the lower respiratory system
that is now breathing dry unfiltered air.
- Hypertrophied turbinates may be the sole cause of nasal
obstruction and frequent infections (see Image 9). These can be
reduced safely by submucous resection of the turbinates. Make an
incision inferiorly that is three fourths the length of the turbinate.
Elevate the mucosa from the bone medially and laterally. Remove the
bone, allowing the turbinate to move medially. Sutures are not usually
placed. In healing, much of the submucosal blood vessels are reduced.
Here, the mucosa is spared.
- Another technique is radiofrequency therapy. One such device is
the somnoplasty turbinate instrument. Here, the instrument is inserted
submucosally, and the radiofrequency spares the mucosa. This is an
office procedure but may require more than one sitting.
- Removal of turbinates: Whichever technique is used in sinus and
turbinate surgery, emphasis must be on preservation of nasal mucosa.
Once the inferior and middle turbinates are removed, the patient has
little defense to prevent chronic sinusitis. These patients have severe
symptoms, and the lower respiratory system may be adversely affected as
well.
Consultations: When the patient has frequently not
responded to antibiotic treatment and other measures, consultation with an
otolaryngologist is indicated. When good treatment is unsuccessful,
frequently, an anatomic defect with obstruction of drainage is found. A
limited CT scan showing blockage of the maxillary sinus requires a
consultation with an otolaryngologist.
- If allergy management does not improve nasal or chest breathing,
consult with an otolaryngologist. Usually, findings are a severely
hypertrophied turbinate that requires surgical attention or a sinus
blockage, which may be the cause of treatment failure.
- When treatment is consistently unsuccessful, consult with a
hematologist or immunologist to rule out hematologic diseases and AIDS.
Disorder of the globulin factors may be the cause.
- When no obvious anatomic defect is present, yet infection defies
treatment, check the hospital culture resistance and sensitivities.
Local bacteria may be highly resistant to the antibiotic presently
administered, and change can be guided by reviewing common hospital
growths and resistance. Sometimes, referral to an infectious disease
specialist is needed. Irrigation to restore cilia action is important
regardless of what antibiotic is used.
- Keep in mind that recurrent sinus infection (eg, 4 infections in 5
mo) is most likely the same infection that never cleared in the first
place. When the sinus infection involves bone, consider intravenous
treatment with appropriate medications. Some stubborn bacterial
infections respond to hyperbaric treatments. Expect serous otitis when
treating sinusitis with hyperbaric oxygen.
- Candidiasis and mold infection, which may occur in individuals with
immune suppression, can be observed with the naked eye as a
characteristically snowy white presence on MRI. Often associated with
polyps, candidiasis and mold infection have very poor response to
antifungal medications. Surgery and medications are needed. Another form
of candidiasis is observed in cases of chronic sinusitis. Here, the
fungus normally present elicits an eosinophilic response, resulting in
release of eosinophilic toxic products that cause illness and poor
response to sinus management. Local irrigation with antifungal
medications may help. Other treatments being tried are fungal
desensitization.
Diet: One of the common urban myths is that milk makes
mucus. Of course, certain persons may be allergic to milk, but the popular
belief that avoiding milk prevents sinusitis is a myth. On the other hand,
it seems to be the kind of information that sells popular books.
- Hot tea: For singers, actors, and speakers, emphasize that hot tea
with lemon and honey helps thin mucus and move the cilia; this treatment
is especially recommended before a performance. Adequate hydration not
only helps the sinus and chest, it can also reduce nosebleeds that many
performers get when traveling or in desert climates.
- Iced drinks: Iced drinks make the allergy worse and slow the cilia.
Many allergy symptoms can be reduced by avoiding iced drinks and
avoiding getting chilled.
- Breakfast in bed: The individual with allergies warms the body by
the actions of sneezing, hacking, and coughing. These actions do work to
warm the body, but they start the cascade of symptoms of allergy. Often,
50% of these symptoms can be avoided by drinking a hot drink (eg, tea)
before getting out of bed. Use a thermos or automatic percolator for the
hot drink and eat a cookie or whatever else is desired. Afterwards, when
the blankets are removed and the feet touch the cold floor, the body is
already warmed and the coughing and sneezing are not necessary to warm
the body. In addition, because of the tea stimulating the cilia, the
dust that accumulated in the nose is removed and sneezing for dust
removal is unnecessary. (Incidentally, each night the hotels in China
provide their guests with hot tea in a thermos.)
Activity: For chest problems and postural drainage,
breathing exercises are important. With shallow breathing, mucus can be
trapped in distal tubules and generate bacterial infection. Stress deep
breathing to remove distal air.
- For exhaustion stage of allergy, when all treatments seem to have
failed, simply going to full bed rest replenishes the body's cortisone
level and often cures the symptoms.
- In acute sinusitis, resting in bed and avoiding getting chilled are
important parts of the therapy.
Asthmatic treatment requires combinations
of smooth muscle relaxants, bronchodilators, and anti-inflammatory
medications. Because asthma is considered an inflammatory condition,
antibiotics may be required as well. Sinusitis requires drainage of the
infection, encouragement of mucociliary flow, and usually, antibiotics.
Often, both asthma and sinusitis are treated simultaneously. Remember that
what affects the sinus or chest affects the entire upper respiratory
system.
Drug Category: Short-acting beta2-adrenergic
agonists -- Often for daily and acute use. Rapid action on
smooth muscles in bronchi. For onset of asthma and for exercise induced
asthma. Abbreviations include the following: MDI metered dose inhaler, EIA
exercise induced asthma, CDN compressor type nebulizer, DPI dry powder
inhaler, and HFA Hydrofluoroalkane (ozone friendly propellent). Note:
Holding chambers and spacers are terms used interchangeably.
Drug Name |
Albuterol (Proventil, Ventolin) --
Beta-agonist for bronchospasm. Relaxes bronchial smooth muscle by
action on beta2 receptors with little effect on cardiac muscle
contractility. Available as inhaler or as tab. Inhaler used
for acute episodes of bronchospasm or for prevention of
bronchospasm. For EIA. Other drugs in this class include bitolterol
(Tornalate), levalbuterol (Xopenex), metaproterenol (Alupent),
pirbuterol (Maxair), and terbutaline (Brethaire, Brethine,
Bricanyl). |
| Adult Dose |
MDI: 2 puffs q4-6h; not to exceed
12 inhalations/d DPI: 1 cap q4-6h CDN: 2.5 mg
tid/qid Syr: 5-10 mL q6h |
| Pediatric Dose |
<4 years: Not
established >4 years: MDI: 2 puffs qid DPI: 1 cap
q4-6h Syr: 5 mL q6h |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Beta-adrenergic blockers antagonize
effects; inhaled ipratropium may increase duration of
bronchodilatation by albuterol; cardiovascular effects may increase
with MAOIs, inhaled anesthetics, TCAs, and sympathomimetic agents
|
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Caution in hyperthyroidism,
diabetes mellitus, convulsive disorders, and cardiovascular
disorders; tachycardia, smooth muscle tremor, hypokalemia, and
increased lactic acid may occur; beta-receptor blockers inhibit
albuterol action; large IV albuterol doses may aggravate preexisting
diabetes mellitus |
Drug Name |
Metaproterenol (Alupent) --
Bronchodilator administered by inhalation. Rapid onset of action.
Activates adenyl cyclase. Potent beta-adrenergic stimulator. Has
preferential effect on beta2-adrenergic receptors compared to
isoproterenol. For asthma and bronchial spasm of bronchitis and
emphysema. Aerosol contains 150 mg of metaproterenol for
inhalation. Available as inhaler, solution for inhalation, syr, and
as 10- or 20-mg tab. |
| Adult Dose |
MDI: 1-3 puffs initial; repeat in 3
h; total dose is 12 times q24h; delivers 0.65 mg of metaproterenol
sulphate; can be used with a positive pressure device Tab: 20
mg PO tid |
| Pediatric Dose |
6-9 years: 5 mL syr PO
tid/qid >9 years: 10 mL syr PO tid/qid Tab: 10 mg PO
tid Nebulizer (6-12 y): 0.1 mL single dose of 5% sol |
| Contraindications |
Documented hypersensitivity;
cardiac arrhythmias or tachycardias |
| Interactions |
Beta-adrenergic blockers antagonize
effects; cardiovascular effects may increase with MAOIs, inhaled
anesthetics, tricyclic antidepressants, and sympathomimetic agents
|
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Titrate dose; caution in
hyperthyroidism, diabetes mellitus, and cardiovascular disorders;
decreased serum potassium may occur |
Drug Category: Anticholinergic agents -- The
parasympatholytic inhalers inhibit vagally mediated reflexes by
antagonizing the action of acetylcholine released by the vagus nerve. This
prevents the increase in intracellular concentration of cyclic guanosine
monophosphate (GMP) caused by interaction of acetylcholine and muscarinic
receptor on bronchial smooth muscle. Help reduce mucus in the
lungs. Relax the smooth muscles of the large and medium bronchi. May be
used with short-acting beta2-adrenergic bronchodilators (eg, albuterol).
Drug Name |
Ipratropium (Atrovent) --
Chemically related to atropine. Has antisecretory properties, and
when applied locally, inhibits secretions from serous and seromucous
glands lining the nasal mucosa. Site-specific effect, not systemic.
Not used PO. Also available as combination product with albuterol
(Combivent). |
| Adult Dose |
MDI: 18 mcg/puff; 2-3 puffs q6h;
not to exceed 12 inhalations/d CDN: 1 vial q6-8h |
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Drugs with anticholinergic
properties (eg, dronabinol) may increase toxicity; albuterol may
increase effects |
| Pregnancy |
B - Usually safe but benefits must
outweigh the risks. |
| Precautions |
Not indicated for acute episodes of
bronchospasm; caution in narrow-angle glaucoma, prostatic
hypertrophy, and bladder neck obstruction; temporary blurring of
vision may occur because of anticholinergic
effects | Drug Category:
Corticosteroids, inhaled -- From the cortex of the adrenal
glands comes one of the more common classes of drugs used in cases of
sinusitis and asthma. This class was discovered and named by Hans Selye
while working with stressed rats. Selye described the action and named the
chemical before the drug was actually identified. His work stimulated the
search for and identification of corticosteroids. For asthma, these drugs
(1) decrease inflammation and swelling in the airways, lessening airway
hyperreactivity; (2) reduce the release of body chemicals from certain
inflammatory cells; and (3) increase the effect of bronchodilator
medications.
Drug Name |
Beclomethasone (Beclovent,
Vanceril, QVAR-HFA) -- Inhibits bronchoconstriction mechanisms and
produces direct smooth muscle relaxation. May decrease number and
activity of inflammatory cells, in turn decreasing airway
hyper-responsiveness. Various dose preparations are available and
must be titrated in conjunction with other medications patient is
taking; most inhaled PO medications have effect in 24 h. Other
drugs in this category include beclomethasone (Beclovent),
budesonide (Pulmicort, Turbuhaler), flunisolide (AeroBid, AeroBid
M), fluticasone (Flovent), and triamcinolone (Azmacort). |
| Adult Dose |
42 mcg: 4-12 puffs/d up to 20
puffs/d |
| Pediatric Dose |
42 mcg: 2-8 puffs/d up to 16
puffs/d |
| Contraindications |
Documented hypersensitivity;
bronchospasm; status asthmaticus; other types of acute episodes of
asthma |
| Interactions |
Coadministration with ketoconazole
may increase plasma levels but does not appear to be clinically
significant |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Caution in diabetes mellitus,
glaucoma, ulcerative intestinal conditions, and pregnancy; weight
gain, increased bruising, cushingoid features, acneiform lesions,
mental disturbances, and cataracts may occur (taper medication
slowly if these changes occur) |
Drug
Category: Corticosteroids, systemic -- Oral steroids are
administered as a short-term burst or as routine maintenance therapy.
Prednisone or methylprednisolone are recommended because they are short
acting and reliably well absorbed and available to the lungs.
Drug Name |
Prednisone (Deltasone) --
Glucosteroid that occurs naturally and synthetically. Used for both
acute and chronic asthma. May decrease inflammation by reversing
increased capillary permeability and suppressing PMN
activity. Loading or initial dose should be taken all at once in
the am; may suppress natural cortisone production; hence, requires
tapering the dose upon discontinuation. As soon as the dose for
relief is found, a maintenance dose may be established until the
nonsteroidal drugs are effective; must always use a decreasing dose
to avoid serious renal suppression. For nasal polyps, the above
dose should be combined with an antibiotic because the stasis of the
polyp generally produces localized bacterial infection. In
seasonal allergy a booster of prednisone may speed resolution of
symptoms. Quite effective in exhaustion stage of seasonal
allergy. Other drugs in this category include methylprednisolone
(Medrol) and prednisolone (Delta-Cortef, Pediapred, Prelone).
|
| Adult Dose |
Allergic rhinitis: 5 mg number 21
PO; prescribed in diminishing doses: 6 tab day 1, 5 tab day 2, and
so on to 1 tab the 6th d; all should be taken at once and not spaced
out Other programs: Up to 60 mg qd or every other dose to control
symptoms or 40-60 mg for 3-10 d |
| Pediatric Dose |
0.25-2 mg/kg qd or q2d
|
| Contraindications |
Documented hypersensitivity; viral
infection; peptic ulcer disease; hepatic dysfunction; connective
tissue infections; fungal or tubercular skin infections; GI disease
|
| Interactions |
Coadministration with estrogens may
decrease prednisone clearance; concurrent use with digoxin may cause
digitalis toxicity secondary to hypokalemia; phenobarbital,
phenytoin, and rifampin may increase metabolism of glucocorticoids
(consider increasing maintenance dose); monitor for hypokalemia with
coadministration of diuretics |
| Pregnancy |
B - Usually safe but benefits must
outweigh the risks. |
| Precautions |
Abrupt discontinuation of
glucocorticoids may cause adrenal crisis; thinning of bones (ie,
osteoporosis, which may lead to fractures or compressions,
especially of the vertebral bones, ie, backbone), loss of blood
supply to bones (ie, aseptic necrosis, which may cause severe bone
pain and may require surgical correction), hypertension, glaucoma,
cataracts, weight gain with increased appetite, fluid retention and
stretch marks, facial fullness, increase in body hair and acne, easy
bruising and thinning of the skin, along with poor wound healing,
interference with growth in children, muscle weakness or cramps,
joint pain, changes in menstrual cycle, diabetes mellitus,
suppression of the body's adrenal gland (which makes necessary the
amount of cortisol at times of stress, ie, adrenal insufficiency,
adrenal gland function usually resumes when steroids are stopped or
when they are taken in a single am or pm dose qod), irritability,
depression, euphoria, or hallucinations may occur with
glucocorticoid use | Drug Category:
Methylxanthines -- Oral theophylline is an old standby
related to caffeine. Not as popular now with the availability of more
specific medications with fewer adverse effects. Can be used in
combination with inhaled corticosteroids. Long duration of action makes it
useful for nighttime asthma. Not recommended as a rescue medication.
Drug Name |
Theophylline (Uni-Dur, Uniphyl,
Theo-Dur, Theo 24, Slo-bid, Gyrocaps) -- Potentiates exogenous
catecholamines, stimulates endogenous catecholamine release, and
diaphragmatic muscular relaxation, which in turn stimulates
bronchodilation. Generally added in order to reduce corticosteroid
dosage. For bronchodilation, near toxic (>20 mg/dL) levels are
usually required. |
| Adult Dose |
10 mg/kg initial; titrate up to 800
mg/d |
| Pediatric Dose |
10 mg/kg/d initial;
titrate <1 year: Not to exceed 5 mg/kg/d >1 year: Not to
exceed 16 mg/kg/d |
| Contraindications |
Documented hypersensitivity;
uncontrolled arrhythmias; peptic ulcers; hyperthyroidism;
uncontrolled seizure disorders |
| Interactions |
Aminoglutethimide, barbiturates,
carbamazepine, ketoconazole, loop diuretics, charcoal, hydantoins,
phenobarbital, phenytoin, rifampin, isoniazid, and sympathomimetics
may decrease effects of theophylline; theophylline effects may
increase with allopurinol, beta-blockers, ciprofloxacin,
corticosteroids, disulfiram, quinolones, thyroid hormones,
ephedrine, carbamazepine, cimetidine, erythromycin, macrolides,
propranolol, and interferon |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Caution in peptic ulcer,
hypertension, tachyarrhythmias, hyperthyroidism, and compromised
cardiac function; not to inject IV solution >25 mg/min; patients
with pulmonary edema or liver dysfunction are at greater risk of
toxicity because of reduced drug clearance; may cause nausea,
vomiting, cramps, diarrhea, and tremors; may affect school
performance | Drug Category:
Leukotriene modifiers -- Can reduce the intake of inhaled
corticosteroids. May be beneficial in difficult asthma cases. Begin to
work in several hours but require up to a week for full
effect. Leukotrienes are one of the products released in asthma attacks
that causes bronchoconstriction and inflammatory response as well as
increased mucus production. Currently available in tab form, but being
researched as a topical medication for the nose in spray form.
Drug Name |
Montelukast (Singular), Zafirlukast
(Accolate), Zileuton (Zyflo) -- Inhibit the cysteinyl leukotriene.
Leukotrienes are products of arachidonic acid from mast cells and
eosinophiles. They cause bronchial edema, smooth muscle contraction,
and inflammation. A selective binding to the receptor occurs
preventing this reaction. Zafirlukast and montelukast selectively
prevent the action of leukotrienes released by mast cells and
eosinophils. Zileuton inhibits leukotriene formation, which in turn
decreases neutrophil and eosinophil migration, neutrophil and
monocyte aggregation, leukocyte adhesion, capillary permeability,
and smooth muscle contractions. Indicated for the prevention and
maintenance of asthma. |
| Adult Dose |
Montelukast: 10 mg PO
hs Zafirlukast (Accolate): 20 mg PO bid Zileuton (Zyflo): 600
mg PO qid |
| Pediatric Dose |
Montelukast: 2-5 years: 4 mg
chewable PO hs 6-14 years: 5 mg chewable PO
hs Zafirlukast: <12 years: Not established >12 years:
Administer as in adults Zileuton: Not established |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Montelukast: Phenobarbital and
rifampin reduce effects Zafirlukast: Erythromycin and
theophylline decrease serum levels of zafirlukast; aspirin increases
levels of zafirlukast; zafirlukast increases toxicity of
warfarin Zileuton: Increases the toxicity of propranolol,
warfarin, and theophylline |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Not indicated to reverse acute
asthma attacks; not for use as monotherapy in the management of
exercise-induced bronchospasm; with zileuton, caution in liver
disease | Drug Category: Mast cell
stabilizers -- Especially effective for allergy but must be
started weeks before exposure or pollen season, minimum one week. Inhibit
sensitized mast cell degeneration when exposed to specific antigens by
inhibiting the release of mediators from the mast cells. Block calcium
ions from entering the mast cell. Inhibits immediate and nonimmediate
bronchoconstriction. Has no direct action on bronchi.
Drug Name |
Cromolyn sodium (Intal, Nasalcrom)
-- Inhibits degranulation of sensitized mast cells following
exposure to specific antigens. Recommended for prevention of cold-
and exercise-induced asthma. May be effective in persons exposed to
fumes (eg, smog, ozone, sulfur dioxide). Takes weeks to reach full
effectiveness. Not recommended to treat an acute attack. Helps
when exposure to asthma triggers is unavoidable. Useful for pet
exposure or occasional horse exposure. |
| Adult Dose |
MDI: 2 puffs qid Nasal spray: 1
spray qid |
| Pediatric Dose |
MDI: 1-2 puffs qid or prn
|
| Contraindications |
Documented hypersensitivity
|
| Interactions |
None reported |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
May induce bronchospasm; not for
use in severe renal or hepatic impairment; symptoms may reoccur when
withdrawing drug; adverse effects include throat irritation,
dryness, bad taste, wheezing, and nausea |
Drug Category: Antibiotics -- Empiric antimicrobial
therapy must be comprehensive and should cover all likely pathogens in the
context of the clinical setting. Most common organisms are S
pneumoniae, H influenzae, and M catarrhalis.
Drug Name |
Amoxicillin (Amoxil, Trimox) or
amoxicillin with clavulanate (Augmentin) -- Interferes with
synthesis of cell wall mucopeptides during active multiplication
resulting in bactericidal activity against susceptible
bacteria. Clavulanate increases activity of beta-lactam
antibiotics in resistant bacteria. |
| Adult Dose |
Amoxicillin: 500 mg PO
tid Amoxicillin and clavulanate: 400-500 mg PO tid |
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Reduces efficacy of PO
contraceptives; coadministration with warfarin or heparin increases
risk of bleeding |
| Pregnancy |
B - Usually safe but benefits must
outweigh the risks. |
| Precautions |
Adjust dose in renal
impairment |
Drug Name |
Trimethoprim and sulfamethoxazole
(Bactrim, Septra DS) -- Inhibits bacterial growth by inhibiting
synthesis of dihydrofolic acid. |
| Adult Dose |
160 mg TMP/800 mg SMZ PO q12h
|
| Pediatric Dose |
<2 months: Not
recommended >2 months: Not established |
| Contraindications |
Documented hypersensitivity;
megaloblastic anemia due to folate deficiency |
| Interactions |
May increase PT when used with
warfarin (perform coagulation tests and adjust dose accordingly);
coadministration with dapsone may increase blood levels of both
drugs; coadministration of diuretics increases incidence of
thrombocytopenia purpura in elderly people; phenytoin levels may
increase with coadministration; may potentiate effects of
methotrexate in bone marrow depression; hypoglycemic response to
sulfonylureas may increase with coadministration; may increase
levels of zidovudine |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Discontinue at first appearance of
skin rash or sign of adverse reaction; obtain CBCs frequently;
discontinue therapy if significant hematologic changes occur;
goiter, diuresis, and hypoglycemia may occur with sulfonamides;
prolonged IV infusions or high doses may cause bone marrow
depression (if signs occur, administer 5-15 mg/d leucovorin);
caution in folate deficiency (eg, chronic alcoholism, old age,
anticonvulsant therapy, malabsorption syndrome); hemolysis may occur
in G-6-PD deficient individuals; AIDS patients may not tolerate or
respond to TMP-SMZ; caution in renal or hepatic impairment (perform
urinalyses and renal function tests during therapy); administer
fluids to prevent crystalluria and stone
formation |
Drug Name |
Clarithromycin (Biaxin),
azithromycin (Zithromax), erythromycin (EES) -- Inhibit bacterial
growth, possibly by blocking dissociation of peptidyl tRNA from
ribosomes causing RNA-dependent protein synthesis to arrest. |
| Adult Dose |
Clarithromycin: 500 mg PO
bid Azithromycin: 500 mg PO on day 1, followed by 250 mg PO qd on
days 2-5 Erythromycin: 250 mg erythromycin stearate/base (or 400
mg ethylsuccinate) q6h PO 1 h ac, or 500 mg q12h; alternatively, 333
mg q8h, increase to 4 g/d depending on severity of infection |
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity;
hepatic impairment; coadministration with pimozide |
| Interactions |
Azithromycin: May increase toxicity
of theophylline, warfarin, and digoxin; effects are reduced with
coadministration of aluminum and/or magnesium antacids;
nephrotoxicity and neurotoxicity may occur when coadministered with
cyclosporine Clarithromycin: Toxicity increases with
coadministration of fluconazole, astemizole, and pimozide;
clarithromycin effects decrease and GI adverse effects may increase
with coadministration of rifabutin or rifampin; may increase
toxicity of anticoagulants, cyclosporine, tacrolimus, digoxin,
omeprazole, carbamazepine, ergot alkaloids, triazolam, and HMG
CoA-reductase inhibitors; cardiac arrhythmias may occur with
coadministration of cisapride; plasma levels of certain
benzodiazepines may increase, prolonging CNS depression; arrhythmias
and increase in QTc intervals occur with disopyramide;
coadministration with omeprazole may increase plasma levels of both
agents Erythromycin: May increase toxicity of theophylline,
digoxin, carbamazepine, and cyclosporine; may potentiate
anticoagulant effects of warfarin; coadministration with lovastatin
and simvastatin increases risk of rhabdomyolysis |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
May increase hepatic enzymes and
cholestatic jaundice; caution in patients with impaired hepatic
function, prolonged QT intervals, or pneumonia; caution in
hospitalized, geriatric, or debilitated patients; diarrhea may be
sign of pseudomembranous colitis; superinfections may occur with
prolonged or repeated antibiotic therapies; coadministration of
clarithromycin with ranitidine or bismuth citrate is not recommended
with CrCl <25 mL/min; administer half dose or increase dosing
interval if CrCl <30 mL/min |
Drug Name |
Cefaclor (Ceclor), cefuroxime
(Ceftin), loracarbef (Lorabid) -- Second-generation cephalosporin
maintains gram-positive activity that first-generation
cephalosporins have. Adds activity against Proteus mirabilis, H
influenzae, Escherichia coli, Klebsiella pneumoniae, and M
catarrhalis. |
| Adult Dose |
Cefaclor: 500 mg PO
tid Cefuroxime: 250 mg PO bid Loracarbef: 400 mg PO bid |
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Disulfiramlike reactions may occur
when alcohol is consumed within 72 h after taking cefuroxime; may
increase hypoprothrombinemic effects of anticoagulants; may increase
nephrotoxicity in patient receiving potent diuretics (eg, loop
diuretics); coadministration with aminoglycosides increases
nephrotoxic potential |
| Pregnancy |
C - Safety for use during pregnancy
has not been established. |
| Precautions |
Reduce dosage by one half if CrCl
is 10-30 mL/min and by one fourth if <10 mL/min; bacterial or
fungal overgrowth of nonsusceptible organisms may occur with
prolonged or repeated therapy |
Drug Name |
Cefixime (Suprax) --
Third-generation cephalosporin. By binding to one or more of the
penicillin-binding proteins it arrests bacterial cell wall synthesis
and inhibits bacterial growth. |
| Adult Dose |
400 mg/d PO qd |
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Coadministration of aminoglycosides
increases nephrotoxicity; probenecid may increase effects of
cefixime |
| Pregnancy |
B - Usually safe but benefits must
outweigh the risks. |
| Precautions |
Adjust dose in renal
impairment |
Drug Name |
Clindamycin (Cleocin) -- Inhibits
bacterial growth, possibly by blocking dissociation of peptidyl tRNA
from ribosomes causing RNA-dependent protein synthesis to arrest.
|
| Adult Dose |
150-300 mg PO q6h
|
| Pediatric Dose |
Not established |
| Contraindications |
Documented hypersensitivity;
regional enteritis; ulcerative colitis; hepatic impairment;
antibiotic-associated colitis |
| Interactions |
Increases duration of neuromuscular
blockade induced by tubocurarine and pancuronium; erythromycin may
antagonize effects of clindamycin; antidiarrheals may delay
absorption of clindamycin |
| Pregnancy |
B - Usually safe but benefits must
outweigh the risks. |
| Precautions |
Adjust dose in severe hepatic
dysfunction; no adjustment necessary in renal insufficiency;
associated with severe and possibly fatal
colitis |
Further Inpatient Care:
- After 1-2 years, if sinusitis symptoms persist (eg, congestion,
drainage, fever, pain), a repeat of the CT scan may be indicated.
- Following surgery, the patient may report not getting enough air,
burning in the nose, and dryness. These symptoms often reflect poor
cilia function. The nasal membranes appear dry and irritable, and they
look thin. Even though the airway is wide open, these symptoms persist
with poor cilia function. Treatment is hydration, nasal moisturizer
sprays, and ointments. Pulsatile irrigation provides relief and helps
restore cilia activity.
- The complications following mid and inferior turbinectomy include
loss of airway resistance and loss of olfactory, tactile, and
temperature sensors (the empty nose syndrome). This may be observed
after bilateral inferior and middle turbinectomy. Symptomatic relief can
be offered by pulsatile irrigation with a Locke-Ringer solution such as
Breathe Ease tid. In this condition, dryness and crusts are prominent.
CT scanning shows mucosal thickening of the paranasal sinuses, loss of
definition of the osteomeatal complex, and enlargement of the nasal
cavity with destruction of the lateral nasal wall. The patients may be
utterly miserable and report the following:
- I can't breathe.
- I can't smell things.
- I can't get enough air.
- My sleep is disturbed.
- I'm plugged up.
- I get frequent infections.
- My ears feel plugged.
- Determine if the symptoms have returned because the patient no
longer keeps environmental precautions. When asthma persists, check for
GERD
- Determine if the polyps returned because the patient is taking
salicylates.
- Ask if the patient acquired a new pet.
- The presence of thick phlegm breeds bacteria and keeps antigens in
the system. Thick phlegm must be controlled with moisturizers and
sufficient liquid and irrigation.
Further Outpatient Care:
- If the cilia of the nose remain normal, few sinus infections should
occur; therefore, efforts should be directed to keeping the cilia of the
nose normal. Use Locke-Ringer or saline (without Benzalkonium) solution
to ensure moisture of the nose. Stress hydration, especially the intake
of hot tea and/or chicken soup. Warm compresses to the sinus area are
important.
- If sinus symptoms persist, review dust proofing of the bedroom with
the patient.
- If cilia of the nose remain slow as shown by dry irritable membranes
and thick phlegm, consider pulsatile irrigation with Locke-Ringer or
saline solution in order to restore cilia. If cilia are permanently
damaged (eg, by excess removal of mucosa, chlorine gas, other toxic
substances), consider pulsatile irrigation daily to keep nose moist and
remove thick phlegm and materials.
- Check for history of nasal polyps on an annual basis. Remind
patients to avoid salicylates. Begin therapy if polyps are recurring.
- On waking up in the morning, the dust has accumulated in the nose
and the body temperature is low. If an individual throws off the covers
and touches the cold floor with the feet, a cascade of sneezing and
hacking warms the body and removes the dust; however, this is an
undesirable method to warm the body. Drinking hot tea before getting out
of bed avoids this morning cascade of sneezing and hacking.
- Cold air and getting chilled can also trigger an asthma attack.
Drinking hot tea before getting out of bed is an excellent preventative.
- The speed of the nasal cilia often reflects the action of the chest
cilia. In difficult asthma with associated coughing, determine whether
the nasal cilia are inactive. Seek the cause. After exposure to
chlorine, chromium, or aldehydes, if the nasal cilia are affected, so
are the chest cilia. Ascertain a medication effect, eg, Benadryl and
chlorpheniramine may slow nasal and chest cilia.
In/Out Patient Meds:
- The continuous medication that is best for individual patients is
variable. Pseudoephedrine with guaifenesin combinations is usually
tolerated well and provides relief. Continued use of a corticosteroid
spray may be indicated. Nonsteroidal sprays such as Astelin may provide
nasal relief.
- Long-term use of the corticosteroids, such as Flonase and Rhinocort
Aqua, may provide symptomatic relief to many patients. Adverse effects
of these and similar products include thinning of membranes and
epistaxis. These effects do not appear until after at least 6 months of
use and may be prevented by alternating with saline without benzalkonium
or Breathe Ease moisturizer spray.
- For patients who continue to catch common colds frequently with
severe symptoms, daily pulsatile irrigation may be beneficial in
reducing incidence of the common cold. Pulsation reduces the amount of
intercellular adhesion molecule-1 (ICAM-1) on the nose. This is the
channel for the common cold virus to enter the nose.
- Hypertonic solutions may provide benefit for short periods when the
nose is boggy and edematous. Usually these solutions irritate after a
while. Try 2 tsp of salt to a pint of water or 2 tsp of Breathe Ease.
Hypertonic solutions can be administered up to 3 times the normal dose
(ie, 3 tsp salt to 1 pt of water). In 1999, Boek recommended
Locke-Ringer solution instead of isotonic sodium solution. When this
solution is made hypertonic (ie, 3 tsp Breathe Ease to 1 pt of water),
less burning occurs because of the electrolyte balance. The author
recommends adding the solutions to boiled or bottled water because many
persons are sensitive to the chlorine in the public water supply.
- Antihistamines in solution work for some patients. Astelin is a
mixture of antihistamine for nasal use. An inexpensive mixture that
patients can use is to dissolve Benadryl 50-mg capsule in an ounce of
Breathe Ease or sodium chloride solution. The dose is variable, and
patients do comment on the taste. Some patients do well with 100 mg of
Benadryl to the 1 oz; therefore, have the patient titrate the dose.
- Patients may continue to experience thick phlegm despite good
surgery, pulsatile irrigation, and nasal moisturizers. Consider inhalant
usage and investigate a food allergy. Try food elimination diets.
Guaifenesin and proteolytic enzymes (eg, Clear Ease) are of help. Stress
adequate fluid intake. If surgery has not been performed, thick nasal
phlegm in the nose reflects similar phlegm in the chest, and efforts
should be directed to thinning the phlegm. Thick phlegm in the chest can
easily become infected. Stress liquids, breathing exercises, postural
drainage, and steam inhalation. Steam inhalation for the chest is
effective if the mouth is open and the tongue is extended.
- In theory, vaporizers moisten the air and thin the mucus. In
practice, they are difficult to keep clean and end up growing mold.
Steam does not reach the lungs intact unless the tongue is extended.
Steam in the shower is very good if the tongue is extended. For
travelers, hang wet towels in the bedroom, set out pans of water (if
available), and fill the bathtub with water and/or set the shower faucet
to drip water.
- Some patients become ill whenever taking an airplane flight. This
can be a serious problem for the patient with a sinus/asthma condition.
In theory (and in practice for this author's patients), placing an
antibiotic ointment, such as Bactroban, in the nose may help by killing
certain bacteria, forming a shield against the other passengers who
cough and sneeze. Patients should avoid iced drinks and drink hot tea to
improve cilia function.
- As in any illness, anxiety can make the illness worse. Recommend
some type of stress reduction technique to be part of the therapy. One
method is to stand before the mirror with the chest exposed. Breathe in
to the count of 4 and out to the count of 6. The exact time for each
breath is not important as long as exhalation is longer than inhalation.
Relax when exhaling. Visualize the face relaxing, the jaw relaxing, and
the shoulders relaxing. The mirror serves as a type of biofeedback
mechanism to tell patients when they are doing the stress reduction
technique correctly. Instruct the patient to do this 10 minutes a day.
With asthma or sinus attack, the complication of anxiety reinforcement
is reduced. Stress reduction techniques are especially valuable for
children.
- Not every salt can be used to make a sodium chloride solution for
irrigation. Regular salt contains silica and iodine. Some patients are
sensitive to this. Sea salt is evaporated and contains various products;
sea salt is high in iodine. These products can be irritating to the
sensitive patient. Kosher salt or pickling salt is free of iodine and
silica. Breathe Ease is based on the Locke-Ringer solution formula with
sodium chloride, calcium chloride, potassium chloride, and sodium
bicarbonate. This balance has been shown to be more effective for cilia
than isotonic sodium chloride solution is.
Deterrence/Prevention:
- Dust proofing is the best deterrence.
- Hot tea thins thick mucus. Thick mucus must be thinned by a
moisturizer or pulsatile irrigation or proteolytic enzymes taken
buccally.
- Elements of the workplace cause sinusitis and asthma. Certain
chemicals are highly toxic to the cilia. These include chromium dust,
sulfur dioxide, smog, ozone, and certain aldehydes (see Dr. Grossan The
Ear, Nose & Throat On-line Consultant). For the individual with
asthma, this may constitute a disability factor. (Discussion of
workplace asthma by pulmonologist Larry Martin can be found at
AllergyBuyersClub.com.)
- For persons who frequently catch the common cold, Rabizza recommends
daily irrigation to remove ICAM-1, which is the entrance factor for this
virus.
- For allergic nasal or chest symptoms, Naso Chrom started 6 weeks
before pollen season often is effective.
- Persons who experience burning or lack of benefit from prepared
nasal moisturizers may be reacting to the preservatives (eg,
benzalkonium). Switch to homemade products.
Complications:
- Complications of sinusitis include the following:
- Generalized infection due to circulatory dissemination of bacteria
- Bronchial infection probably due to direct passage by infected
mucus into the trachea: Bacteria in the sinus appear in the trachea 16
hours later.
- Meningitis via venous and lymphatic drainage into the CNS or by
direct extension through the posterior wall of the frontal sinus or
throughout the olfactory area: Sometimes a fistula may be present
after sinus surgery. If fever develops in a patient who has had sinus
surgery, rule out meningitis and look for fistula, usually in or near
the cribriform plate.
- Cavernous sinus thrombosis: The cavernous sinus is a highly
vascular area containing optic nerves and cranial nerves III, IV, and
VI. It may arise from sphenoid sinusitis.
- Optic spread: Spread can be via the ethmoid sinuses and can cause
orbital cellulitis. Optic spread is more common in children than
adults.
- Asthma complications can be fatal and include the following:
Prognosis:
- Patients with sinusitis and asthma have a good prognosis. When the
allergist and the ENT specialist are available for problems associated
with these diseases, the prognosis is often satisfactory.
- If the patient has experienced failure after sinus surgery, the
prognosis is poorer. Factors such as regrowth of obstructing tissue,
poor response to infection, and poor response to antibiotics suggest
nonoptimum prognosis.
- If the patient's course of sinusitis and asthma has been poor,
review factors of immune response. Consider cystic fibrosis, GERD, HIV,
and/or systemic infection.
- Hypothyroidism is associated with allergy conditions. Often,
specific allergy desensitization may initially be unsuccessful and then
succeed when thyroid supplement is added.
Patient Education:
- Patient education includes dust-proofing instructions. Encourage
patients to keep the bedroom free of dust and mold (see Sinusitis: A
Treatment Plan That Works for Asthma and Allergies Too for details).
- Instruct patients to keep the nose moist with moisturizer.
- Educate patients regarding importance of adequate hydration.
- Instruct patients to keep windows of bedroom closed at 5 am and 5
pm. This is when the plants pollinate. Allergic patients do better when
they have hot tea before getting out of bed in the morning.
- Educate patients regarding the availability of pollen calendars (see
AllergyBuyersClub.com). For allergy, if cromolyn nasal spray is started
6 weeks before the season, excellent results are possible.
- Dogs, cats, and birds must be kept out of the bedroom.
- Instruct patients to drive with car windows closed, especially in
the late afternoon.
- Teach adults and children to blow the nose gently with both sides
open. Instruct patients how to clear the ears.
- Educate patients about dust proofing the environment. Many allergy
companies supply free booklets detailing the dust-proofing instructions.
These should be a significant part of the armamentarium of treatment of
sinusitis and asthma. Usually, during the third visit to the physician's
office, the patient hears the instructions regarding dust proofing;
after the fifth office visit, patients actually start the dust-proofing
process. Make sure the instructions include no smoking. Repeat the
instructions regarding dust proofing, daily breath exercises, and peak
flow measurements with each patient visit to the office.
- For excellent patient education resources, see eMedicine's Asthma
Center and Headache Center. Also, visit eMedicine's patient education
articles, Asthma, Asthma FAQs, Understanding Asthma Medications, and
Sinus Infection.
Medical/Legal Pitfalls:
- Failure to diagnose pneumonia: One frequent pitfall involves the
patient who is miserable with sinusitis and coughing. Whatever the
medical specialty, the physician must listen to the chest and look for
asthma, pneumonia, wheezing, and/or a silent lung. Just because
sinusitis is present, the physician cannot assume that this is the only
cause of the cough. One problem, of course, is that some ENT specialists
are not expert at listening to the chest; however, the physician must
listen and document that action. When in doubt, refer to a pulmonologist
or an internist. Failure to recognize asthma or pneumonia in the
presence of sinusitis is an area of litigation.
- Cerebral spinal fluid fistula: The ENT surgeon works in the roof of
the nose where the skull and contents are thinly separated (see Image
10). The CT scan must be in the operating room, and the surgeon must
look for deep areas where the floor of the skull descends below ordinary
areas. A dehiscence may already be present. Recognizing this
complication is important. Look for signs of meningitis and unusual
headache postoperatively. Sometimes these signs are masked by the
antibiotics. A unilateral clear drainage following surgery carries a
very high suspicion of a fistula. Laboratory tests are used to determine
if this is cerebral spinal fluid. These fistulae can be closed via
endoscopic route. The important thing is to make the proper diagnosis.
Failure to make the diagnosis can lead to litigation.
- Eye complications: Surgery on the ethmoid sinuses can lead to
entrance into the globe of the eye. With the increased bleeding, this
complication may not be recognized. Any visual disturbance or muscle
paralysis postsurgery should suggest a surgical eye complication. Often
these eye complications are difficult to repair.
- Sphenoid sinus: The lateral walls of the sphenoid sinus contain the
cavernous sinuses and the various ocular nerves. These areas are rarely
compromised because normally the walls are thick.
- Anosmia: Anosmia is not an infrequent complication. As soon as the
instrument strays to the midline, the cribriform plate, which contains
the olfactory nerve endings, can be affected. A frequent cause is
septoplasty in which the bone is rocked by forceps. Rocking the bone in
order to break it can easily move the ethmoid bone, thereby disrupting
the olfactory nerves. Always use biting forceps in this area to prevent
anosmia. This complication is not reparable.
- Atrophic rhinitis: Postoperatively, the nose may look wide open;
however, the patient is miserable, the nose is dry, and the normal
functions of moistening the air, heating the air, and trapping bacteria
in mucus are now gone because the mucosa of the turbinates have been
removed. Turbinectomy, unless performed so as to preserve mucosa and
function, can leave the patient highly symptomatic and ready to
litigate. Prevention is to preserve turbinate mucosa. See empty nose
syndrome.
- Allergy: Failure to diagnose allergy may lead to litigation. The
patient may be misdiagnosed with sinusitis. An excellent surgery is
performed to straighten the septum and move the turbinates.
Postoperatively, the patient still has nasal obstruction and the
physician recommends a second operation. The patient goes to an
allergist who clearly demonstrates a 4 plus dust allergy, and the
patient's condition clears on desensitization. Now, the patient is ready
to legally sue the surgeon because surgery was not necessary. Performing
surgery with the knowledge that an allergy condition exists and
explaining that the allergy condition will either persist or improve
after surgery is not a problem; however, to not offer the patient the
choice of allergy therapy versus surgery is a failure of good medicine.
- Medications: The patient may be taking medicine from an orthopedist,
an endocrinologist, a psychiatrist, and an internist. Because of drug
interaction concerns, at times the otolaryngologist can only prescribe
sodium chloride solution for the patient. Drug interaction is a serious
problem and one that can easily lead to litigation. Somewhere in the
literature the lawyer can find a case where one drug should not be
administered with another drug. One defense is to insist that the
patient only use a single pharmacist who, hopefully, looks at these
interactions. Another is to speak with the internist or the hospital
pharmacist.
- Frontal sinusitis: Following endoscopic surgery, the attachment of
the middle turbinate may move so as to block the frontal sinus. Look for
this etiology when a history of prior endoscopic procedures is present.
Even in this golden age of antibiotics, frontal sinus abscesses do
occur. They may rupture through the posterior wall into the brain. The
difficulty with this diagnosis comes with the patient who is seen weekly
who has severe symptoms, including frontal headache. When a
noncomplaining patient reports frontal pain, consider frontal sinusitis.
A CT scan (not an MRI) must be obtained to evaluate the posterior wall
of the frontal sinus.
- Prednisone: Never refill prednisone. Good doctors do forgot to write
"do not refill" on the prescriptions, and patients do keep refilling
these prescriptions. Alternatively, the physician can refill a
prescription by phone and not see that the patient has Cushing disease.
Always write "do not refill" on prednisone and similar
medications. Patients often feel great on prednisone and will think
of ways to get more, including altering the prescription or calling the
physician's associate or registered nurse.
- The chart: One pitfall is a chart that does not adequately describe
the lesion and does not include pictures or diagrams. At surgery, any
description of the deviated septum is similarly absent in the chart.
Include pictures, diagrams, and descriptions with documentation in the
chart so a lawyer cannot claim that surgery was not indicated. Insurance
carriers look for ways to avoid payments, and a chart without adequate
documentation makes this easy for them.
- Discussion of complications: Writing "complications were discussed"
is acceptable, but the patient may still insist that no discussion
occurred. In one such case, the office chart and hospital chart were
complete and nicely written. Dictation regarding the surgery occurred
right after the operation. The dictation was complete, and the important
details were included. This case was easy to legally defend because any
doctor with such thorough charts would obviously be just as thorough in
explaining the complications.
- Written instructions: For example, one patient puts the eardrops in
the mouth; another patient puts the liquid penicillin in the nose and
then claims that the physician verbally instructed that the penicillin
was for the nose. Always assume the worst-case scenario and write the
instructions separately from verbal instructions. Keep a copy of the
written instructions.
- Speaking the patient's language: Using terms and analogies that the
patient really understands is necessary. Use pictures, diagrams, and
other communication tools. Have the patient hold the skull while
explaining the surgery.
- Discussing the alternatives: The moment the doctor mentions surgery
the patient may dismiss it as a possible treatment. Advise the patient
of alternative care. Options include (1) continuing with medication,
which has not worked; (2) trying 2 years of allergy shots; (3) trying
more cortisone and risking the adverse effects; or (4) trying surgery.
In a good practice, patients usually have already explored all options,
so surgery is the remaining option.
- Adequate medical course: The guidelines for ENT surgery are clear
that the nonsurgical approach must be tried before surgery.
Complications at sinus surgery do occur. A lawyer may argue that the CT
scan showed thickened membranes. In other words, the lawyer is implying
that the physician could have prescribed antibiotics and cleared the
membranes without surgery. Another example is if the patient had polyps.
A lawyer may quote a medical expert who says that a physician should
always try medication to shrink the polyps. The lawyer then asks why
this medication was not tried and implies that the physician was anxious
to sell an operation. No matter what procedure is performed, some
article can always be found that reports that the procedure either
should not be performed or should be performed differently. Be aware of
the other opinions in the medical field because the opposing attorney
will be aware of these options.
- Expecting the worst: From the author's experience, using diagrams,
speaking clearly, and using words that the mother seemed to understand,
this author explained the need for adenoidectomy and myringotomy for her
child and then asked if she had any questions. An hour later, the
mother's doctor called to report that the mother was in his office
crying because nothing had been explained to her regarding surgery.
- The “never operate” argument: A favorite legal ploy is reporting
that the medical expert says never operate on patients with this
condition. This quote may be taken out of context and may be taken from
a medical journal written in a foreign language. Demand to see or read
the entire article.
| Caption: Picture 1. Asthma and
sinusitis. Lateral sinus wall. Perform nasal endoscopy to reveal
patent or closed sinus ostia. Look for purulent areas. |
 |
| Picture Type:
Image |
| Caption: Picture 2. Asthma and
sinusitis. Septal deviation with concha bullosa. On the CT scan, the
bony anatomy, including the important structures of the maxillary
frontal and sphenoid ostia, is detailed. The cribriform plate, whose
anatomic position is a critical factor in any surgery, is
visualized. The surgeon looks for depression at this area and
dehiscence. In the image, the septum is deviated to the left, and
the concha bullosa is right of the middle turbinate. |
 |
| Picture Type:
Image |
| Caption: Picture 3. Asthma and
sinusitis. Lateral wall anatomy, nasal endoscopy. Patent or closed
sinus ostia may be revealed. The maxillary, frontal, and sphenoid
ostia are visualized. Purulent discharge is noted. |
 |
| Picture Type:
Image |
| Caption: Picture 4. Asthma and
sinusitis. Hydro Pulse Irrigator. Because bacteria and thick phlegm
play a significant role, the physician can reduce the asthmatic
symptoms from sinusitis by suctioning or irrigating in the office if
pus is present in the nose or sinuses. One technique is to use a
vasoconstrictor in the nose, wait 2 minutes, and then irrigate with
a modified Locke-Ringer solution or sodium chloride solution with a
pulsatile nasal irrigator. Not only is a considerable amount of
surface and sinus pus removed, but the pulsatile action at 20 pulses
per second stimulates the cilia of the nose and sinuses to restore
normal cilia action. Flow of solution past the orifice creates a
Bernoulli effect to displace the sinus contents. The additional
pulsation aids this process. |
 |
| Picture Type:
Photo |
| Caption: Picture 5. Asthma and
sinusitis. Radiograph of a child. Note the size of maxillary
sinuses. Ethmoids are beginning to develop, but the frontal sinus is
not yet present. One useful technique for treating sinusitis in
children is Proetz sinus irrigation, which is performed with the
child hyperextended over the parent's lap so that the child's head
is lowered. |
 |
| Picture Type:
X-RAY |
| Caption: Picture 6. Asthma and
sinusitis. Concha bullosa. Blockage of the natural ostia can be
caused by a foreign body. A deviated septum may compress this area.
Hypertrophy of turbinates may be sufficient to block the opening.
Concha bullosa refers to a hollow enlargement of the middle
turbinate so that it blocks drainage of the maxillary ostia. |
 |
| Picture Type:
Image |
| Caption: Picture 7. Asthma and
sinusitis. Nasal polyps may develop in the opening itself or grow
from a distal origin and be positioned to obstruct the ostia.
Treatment is directed to ensure sinus patency and to remove
obstructive septum, polyps, and tissue. |
 |
| Picture Type:
Photo |
| Caption: Picture 8. Asthma and
sinusitis. The most common ENT surgery is correction of a deviated
septum. Because of multiple injuries, the septum is no longer in
midline. When it blocks breathing (see Image 2), the entire airflow
pattern can be upset, or the septum may impact solidly against the
sides (septal spur) and cause blockage of drainage from sinuses.
|
 |
| Picture Type:
Image |
| Caption: Picture 9. Asthma and
sinusitis. Hypertrophied turbinates may be the sole cause of nasal
obstruction and frequent infections. These can be safely reduced by
submucous resection of the turbinates. |
 |
| Picture Type:
Image |
| Caption: Picture 10. Asthma and
sinusitis. Cerebral spinal fluid fistula. The ENT surgeon works in
the roof of the nose where the skull and contents are thinly
separated. |
 |
| Picture Type:
CT |
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